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Joint Instability and Osteoarthritis
Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337591/ https://www.ncbi.nlm.nih.gov/pubmed/25741184 http://dx.doi.org/10.4137/CMAMD.S22147 |
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author | Blalock, Darryl Miller, Andrew Tilley, Michael Wang, Jinxi |
author_facet | Blalock, Darryl Miller, Andrew Tilley, Michael Wang, Jinxi |
author_sort | Blalock, Darryl |
collection | PubMed |
description | Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA. |
format | Online Article Text |
id | pubmed-4337591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-43375912015-03-04 Joint Instability and Osteoarthritis Blalock, Darryl Miller, Andrew Tilley, Michael Wang, Jinxi Clin Med Insights Arthritis Musculoskelet Disord Review Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA. Libertas Academica 2015-02-19 /pmc/articles/PMC4337591/ /pubmed/25741184 http://dx.doi.org/10.4137/CMAMD.S22147 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Review Blalock, Darryl Miller, Andrew Tilley, Michael Wang, Jinxi Joint Instability and Osteoarthritis |
title | Joint Instability and Osteoarthritis |
title_full | Joint Instability and Osteoarthritis |
title_fullStr | Joint Instability and Osteoarthritis |
title_full_unstemmed | Joint Instability and Osteoarthritis |
title_short | Joint Instability and Osteoarthritis |
title_sort | joint instability and osteoarthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337591/ https://www.ncbi.nlm.nih.gov/pubmed/25741184 http://dx.doi.org/10.4137/CMAMD.S22147 |
work_keys_str_mv | AT blalockdarryl jointinstabilityandosteoarthritis AT millerandrew jointinstabilityandosteoarthritis AT tilleymichael jointinstabilityandosteoarthritis AT wangjinxi jointinstabilityandosteoarthritis |