Defective apical extrusion signaling contributes to aggressive tumor hallmarks

When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P(2) receptors in neighboring cells that seamlessly squeeze the cell out of the epithelium. Here, we find that extrusion defects can cont...

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Detalles Bibliográficos
Autores principales: Gu, Yapeng, Shea, Jill, Slattum, Gloria, Firpo, Matthew A, Alexander, Margaret, Mulvihill, Sean J, Golubovskaya, Vita M, Rosenblatt, Jody
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337653/
https://www.ncbi.nlm.nih.gov/pubmed/25621765
http://dx.doi.org/10.7554/eLife.04069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337653/
https://www.ncbi.nlm.nih.gov/pubmed/25621765
http://dx.doi.org/10.7554/eLife.04069

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