Cargando…
Defective apical extrusion signaling contributes to aggressive tumor hallmarks
When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P(2) receptors in neighboring cells that seamlessly squeeze the cell out of the epithelium. Here, we find that extrusion defects can cont...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337653/ https://www.ncbi.nlm.nih.gov/pubmed/25621765 http://dx.doi.org/10.7554/eLife.04069 |