Cargando…

Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential

Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitra, Joy, Vasquez, Velmarini, Hegde, Pavana M, Boldogh, Istvan, Mitra, Sankar, Kent, Thomas A, Rao, Kosagi S, Hegde, Muralidhar L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337781/ https://www.ncbi.nlm.nih.gov/pubmed/25717476 http://dx.doi.org/10.14437/NRTOA-1-107

Ejemplares similares

New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases
por: Mitra, Joy, et al.
Publicado: (2014)

Human DNA Glycosylase NEIL1’s Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival
por: Hegde, Muralidhar L., et al.
Publicado: (2012)

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients
por: Mitra, Joy, et al.
Publicado: (2019)

Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
por: Patel, Pooja R, et al.
Publicado: (2015)

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
por: Yang, Chunying, et al.
Publicado: (2017)

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
por: Wang, Haibo, et al.
Publicado: (2018)

Introduction to The Special Issue: Novel Molecular Pathways and Therapeutic Challenges in Neurodegenerative Diseases
por: Kosagisharaf, Jagannatha Rao, et al.
Publicado: (2023)

A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis
por: Mitra, Joy, et al.
Publicado: (2019)

SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
por: Mitra, Joy, et al.
Publicado: (2022)

FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration
por: Kodavati, Manohar, et al.
Publicado: (2023)

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
por: Lakey-Beitia, Johant, et al.
Publicado: (2019)

Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
por: Rangaswamy, Suganya, et al.
Publicado: (2017)

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
por: Hegde, Muralidhar L., et al.
Publicado: (2016)

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
por: Dutta, Arijit, et al.
Publicado: (2017)

The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis
por: Derry, Paul J., et al.
Publicado: (2020)

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
por: Wang, Haibo, et al.
Publicado: (2017)

DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders
por: Provasek, Vincent E., et al.
Publicado: (2022)

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
por: Sengupta, Shiladitya, et al.
Publicado: (2020)

lncRNA Sequencing Reveals Neurodegeneration-associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists In Motor Neurons
por: Provasek, Vincent E., et al.
Publicado: (2023)

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
por: Bacolla, Albino, et al.
Publicado: (2020)

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
por: Chatterjee, Arpita, et al.
Publicado: (2015)

lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons
por: Provasek, Vincent E., et al.
Publicado: (2023)

Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks
por: Chakraborty, Anirban, et al.
Publicado: (2023)

New Mechanisms of DNA Repair Defects in Fused in Sarcoma–Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?
por: Wang, Haibo, et al.
Publicado: (2019)

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells
por: Chattopadhyay, Ranajoy, et al.
Publicado: (2006)

The gut microbiota in neurodegenerative diseases: revisiting possible therapeutic targets for cannabidiol
por: Oliveira, Bruna Stefane Alves de, et al.
Publicado: (2022)

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation
por: Ba, Xueqing, et al.
Publicado: (2014)

RT(2) PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
por: Wang, Haibo, et al.
Publicado: (2019)

Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases
por: Hegde, Muralidhar L.
Publicado: (2014)

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication
por: Wang, Haibo, et al.
Publicado: (2021)

Editorial: Defective DNA damage response–Repair axis in post-mitotic neurons in human health and neurodegenerative diseases
por: Konopka, Anna, et al.
Publicado: (2022)

Author Correction: Early‑life short‑term environmental enrichment counteracts the effects of stress on anxiety‑like behavior, brain‑derived neurotrophic factor and nuclear translocation of glucocorticoid receptors in the basolateral amygdala
por: Hegde, Akshaya, et al.
Publicado: (2020)

Early-life short-term environmental enrichment counteracts the effects of stress on anxiety-like behavior, brain-derived neurotrophic factor and nuclear translocation of glucocorticoid receptors in the basolateral amygdala
por: Hegde, Akshaya, et al.
Publicado: (2020)

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
por: Eckelmann, Bradley J, et al.
Publicado: (2020)

Oxidative Toxicity in Neurodegenerative Diseases: Role of Mitochondrial Dysfunction and Therapeutic Strategies
por: Facecchia, Katie, et al.
Publicado: (2011)

Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress
por: Hegde, Akshaya, et al.
Publicado: (2017)

Speciation in Metal Toxicity and Metal-Based Therapeutics
por: Templeton, Douglas M.
Publicado: (2015)

Mills’ syndrome revisited
por: Jaiser, Stephan R., et al.
Publicado: (2019)

Eccrine Angiomatous Naevus Revisited
por: Sen, Sumit, et al.
Publicado: (2012)

Zebrafish as a Potential Model for Neurodegenerative Diseases: A Focus on Toxic Metals Implications
por: Paduraru, Emanuela, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2rb9tk8d2l6rv2vt9hloo87oui