The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice

2-Fluorofucose (2FF) blocks the fucosylation and the tethering of sialyl-Lewis(x) tetrasaccharide and structural variants on leukocytes and red blood cells to P- and E-selectins on activated endothelial cell surfaces. Because P- and E-selectin are required for vaso-occlusion in murine sickle cell di...

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Detalles Bibliográficos
Autores principales: Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Nguyen, Phong, Nguyen, Minh, Okeley, Nicole M., Benjamin, Dennis R., Senter, Peter D., Vercellotti, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338063/
https://www.ncbi.nlm.nih.gov/pubmed/25706118
http://dx.doi.org/10.1371/journal.pone.0117772

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