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Dosage of the Abcg1-U2af1 Region Modifies Locomotor and Cognitive Deficits Observed in the Tc1 Mouse Model of Down Syndrome

Down syndrome (DS) results from one extra copy of human chromosome 21 and leads to several alterations including intellectual disabilities and locomotor defects. The transchromosomic Tc1 mouse model carrying an extra freely-segregating copy of human chromosome 21 was developed to better characterize...

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Detalles Bibliográficos
Autores principales:	Marechal, Damien, Pereira, Patricia Lopes, Duchon, Arnaud, Herault, Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338106/ https://www.ncbi.nlm.nih.gov/pubmed/25706610 http://dx.doi.org/10.1371/journal.pone.0115302

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