Ozanezumab Dose Selection for Amyotrophic Lateral Sclerosis by Pharmacokinetic-Pharmacodynamic Modelling of Immunohistochemistry Data from Patient Muscle Biopsies

Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal neurodegenerative disease with a high unmet medical need. In this context, a potential therapy should be brought to patients in the most expeditious way and early exploration of pharmacology is highly beneficial. Ozanezumab, a humanised IgG mon...

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Detalles Bibliográficos
Autores principales: Berges, Alienor, Bullman, Jonathan, Bates, Stewart, Krull, David, Williams, Nicola, Chen, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338135/
https://www.ncbi.nlm.nih.gov/pubmed/25706882
http://dx.doi.org/10.1371/journal.pone.0117355

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