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Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

Translocation of a nascent protein from the cytosol into the ER mediated by its signal peptide is a critical step in protein secretion. The aim of this work was to develop a platform technology to optimize the signal peptides for high level production of therapeutic antibodies in CHO cells. A databa...

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Detalles Bibliográficos
Autores principales:	Haryadi, Ryan, Ho, Steven, Kok, Yee Jiun, Pu, Helen X., Zheng, Lu, Pereira, Natasha A., Li, Bin, Bi, Xuezhi, Goh, Lin-Tang, Yang, Yuansheng, Song, Zhiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338144/ https://www.ncbi.nlm.nih.gov/pubmed/25706993 http://dx.doi.org/10.1371/journal.pone.0116878

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