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White matter integrity in small vessel disease is related to cognition
Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-app...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338206/ https://www.ncbi.nlm.nih.gov/pubmed/25737960 http://dx.doi.org/10.1016/j.nicl.2015.02.003 |
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author | Tuladhar, Anil M. van Norden, Anouk G.W. de Laat, Karlijn F. Zwiers, Marcel P. van Dijk, Ewoud J. Norris, David G. de Leeuw, Frank-Erik |
author_facet | Tuladhar, Anil M. van Norden, Anouk G.W. de Laat, Karlijn F. Zwiers, Marcel P. van Dijk, Ewoud J. Norris, David G. de Leeuw, Frank-Erik |
author_sort | Tuladhar, Anil M. |
collection | PubMed |
description | Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter) that connect distributed brain regions involved in cognitive functions. Here, we investigated the relation between microstructural integrity of the white matter and cognitive functions in patients with small vessel disease. The Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort study is a prospective cohort study among 444 independently living, non-demented elderly with cerebral small vessel disease, aged between 5500 and 85 years. All subjects underwent magnetic resonance imaging and diffusion tensor imaging scanning and an extensive neuropsychological assessment. We showed that loss of microstructural integrity of the white matter at specific locations was related to specific cognitive disturbances, which was mainly located in the normal-appearing white matter (p < 0.05, FWE-corrected for multiple comparisons). The microstructural integrity in the genu and splenium showed the highest significant relation with global cognitive function and executive functions, in the cingulum bundle with verbal memory performance. Associations between diffusion tensor imaging parameters and most cognitive domains remained present after adjustment for WMH and lacunes. In conclusion, cognitive disturbances in subjects with cerebral small vessel disease are related to microstructural integrity of multiple white matter fibers (within WMH and normal-appearing white matter) connecting different cortical and subcortical regions. |
format | Online Article Text |
id | pubmed-4338206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-43382062015-03-03 White matter integrity in small vessel disease is related to cognition Tuladhar, Anil M. van Norden, Anouk G.W. de Laat, Karlijn F. Zwiers, Marcel P. van Dijk, Ewoud J. Norris, David G. de Leeuw, Frank-Erik Neuroimage Clin Regular Article Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter) that connect distributed brain regions involved in cognitive functions. Here, we investigated the relation between microstructural integrity of the white matter and cognitive functions in patients with small vessel disease. The Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort study is a prospective cohort study among 444 independently living, non-demented elderly with cerebral small vessel disease, aged between 5500 and 85 years. All subjects underwent magnetic resonance imaging and diffusion tensor imaging scanning and an extensive neuropsychological assessment. We showed that loss of microstructural integrity of the white matter at specific locations was related to specific cognitive disturbances, which was mainly located in the normal-appearing white matter (p < 0.05, FWE-corrected for multiple comparisons). The microstructural integrity in the genu and splenium showed the highest significant relation with global cognitive function and executive functions, in the cingulum bundle with verbal memory performance. Associations between diffusion tensor imaging parameters and most cognitive domains remained present after adjustment for WMH and lacunes. In conclusion, cognitive disturbances in subjects with cerebral small vessel disease are related to microstructural integrity of multiple white matter fibers (within WMH and normal-appearing white matter) connecting different cortical and subcortical regions. Elsevier 2015-02-16 /pmc/articles/PMC4338206/ /pubmed/25737960 http://dx.doi.org/10.1016/j.nicl.2015.02.003 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Tuladhar, Anil M. van Norden, Anouk G.W. de Laat, Karlijn F. Zwiers, Marcel P. van Dijk, Ewoud J. Norris, David G. de Leeuw, Frank-Erik White matter integrity in small vessel disease is related to cognition |
title | White matter integrity in small vessel disease is related to cognition |
title_full | White matter integrity in small vessel disease is related to cognition |
title_fullStr | White matter integrity in small vessel disease is related to cognition |
title_full_unstemmed | White matter integrity in small vessel disease is related to cognition |
title_short | White matter integrity in small vessel disease is related to cognition |
title_sort | white matter integrity in small vessel disease is related to cognition |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338206/ https://www.ncbi.nlm.nih.gov/pubmed/25737960 http://dx.doi.org/10.1016/j.nicl.2015.02.003 |
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