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Regulation of Intestinal Immune System by Dendritic Cells
Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells, are critical sentinels that perform multiple roles in immune responses, from acting as principal...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Immunologists
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338263/ https://www.ncbi.nlm.nih.gov/pubmed/25713503 http://dx.doi.org/10.4110/in.2015.15.1.1 |
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author | Ko, Hyun-Jeong Chang, Sun-Young |
author_facet | Ko, Hyun-Jeong Chang, Sun-Young |
author_sort | Ko, Hyun-Jeong |
collection | PubMed |
description | Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells, are critical sentinels that perform multiple roles in immune responses, from acting as principal modulators to priming an adaptive immune response through antigen-specific signaling. In the gut, DCs meet exogenous, non-harmful food antigens as well as vast commensal microbes under steady-state conditions. In other instances, they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs in maintaining intestinal immune homeostasis. Specifically, we describe how intestinal DCs affect IgA production from B cells and influence the generation of unique subsets of T cell. |
format | Online Article Text |
id | pubmed-4338263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Association of Immunologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-43382632015-02-24 Regulation of Intestinal Immune System by Dendritic Cells Ko, Hyun-Jeong Chang, Sun-Young Immune Netw Review Article Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells, are critical sentinels that perform multiple roles in immune responses, from acting as principal modulators to priming an adaptive immune response through antigen-specific signaling. In the gut, DCs meet exogenous, non-harmful food antigens as well as vast commensal microbes under steady-state conditions. In other instances, they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs in maintaining intestinal immune homeostasis. Specifically, we describe how intestinal DCs affect IgA production from B cells and influence the generation of unique subsets of T cell. The Korean Association of Immunologists 2015-02 2015-02-17 /pmc/articles/PMC4338263/ /pubmed/25713503 http://dx.doi.org/10.4110/in.2015.15.1.1 Text en Copyright © 2015 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ko, Hyun-Jeong Chang, Sun-Young Regulation of Intestinal Immune System by Dendritic Cells |
title | Regulation of Intestinal Immune System by Dendritic Cells |
title_full | Regulation of Intestinal Immune System by Dendritic Cells |
title_fullStr | Regulation of Intestinal Immune System by Dendritic Cells |
title_full_unstemmed | Regulation of Intestinal Immune System by Dendritic Cells |
title_short | Regulation of Intestinal Immune System by Dendritic Cells |
title_sort | regulation of intestinal immune system by dendritic cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338263/ https://www.ncbi.nlm.nih.gov/pubmed/25713503 http://dx.doi.org/10.4110/in.2015.15.1.1 |
work_keys_str_mv | AT kohyunjeong regulationofintestinalimmunesystembydendriticcells AT changsunyoung regulationofintestinalimmunesystembydendriticcells |