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How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme
The need for interfacing structural biology and biophysics to molecular evolution is being increasingly recognized. One part of the big problem is to understand how physics and chemistry shape the sequence space available to functional proteins, while satisfying the needs of biology. Here we present...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338278/ https://www.ncbi.nlm.nih.gov/pubmed/25706742 http://dx.doi.org/10.1371/journal.pone.0118684 |