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How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme

The need for interfacing structural biology and biophysics to molecular evolution is being increasingly recognized. One part of the big problem is to understand how physics and chemistry shape the sequence space available to functional proteins, while satisfying the needs of biology. Here we present...

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Detalles Bibliográficos
Autores principales: Abriata, Luciano A., Palzkill, Timothy, Dal Peraro, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338278/
https://www.ncbi.nlm.nih.gov/pubmed/25706742
http://dx.doi.org/10.1371/journal.pone.0118684

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