Cargando…
How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme
The need for interfacing structural biology and biophysics to molecular evolution is being increasingly recognized. One part of the big problem is to understand how physics and chemistry shape the sequence space available to functional proteins, while satisfying the needs of biology. Here we present...
Autores principales: | Abriata, Luciano A., Palzkill, Timothy, Dal Peraro, Matteo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338278/ https://www.ncbi.nlm.nih.gov/pubmed/25706742 http://dx.doi.org/10.1371/journal.pone.0118684 |
Ejemplares similares
-
Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server
por: Abriata, Luciano A., et al.
Publicado: (2016) -
Erratum to: Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server
por: Abriata, Luciano A., et al.
Publicado: (2016) -
Structural, physicochemical and dynamic features conserved within the aerolysin pore-forming toxin family
por: Cirauqui, Nuria, et al.
Publicado: (2017) -
Assessment of transferable forcefields for protein simulations attests improved description of disordered states and secondary structure propensities, and hints at multi-protein systems as the next challenge for optimization
por: Abriata, Luciano A., et al.
Publicado: (2021) -
Assessing the potential of atomistic molecular dynamics simulations to probe reversible protein-protein recognition and binding
por: Abriata, Luciano A., et al.
Publicado: (2015)