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Violation of an Evolutionarily Conserved Immunoglobulin Diversity Gene Sequence Preference Promotes Production of dsDNA-Specific IgG Antibodies
Variability in the developing antibody repertoire is focused on the third complementarity determining region of the H chain (CDR-H3), which lies at the center of the antigen binding site where it often plays a decisive role in antigen binding. The power of VDJ recombination and N nucleotide addition...
Autores principales: | Silva-Sanchez, Aaron, Liu, Cun Ren, Vale, Andre M., Khass, Mohamed, Kapoor, Pratibha, Elgavish, Ada, Ivanov, Ivaylo I., Ippolito, Gregory C., Schelonka, Robert L., Schoeb, Trenton R., Burrows, Peter D., Schroeder, Harry W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338297/ https://www.ncbi.nlm.nih.gov/pubmed/25706374 http://dx.doi.org/10.1371/journal.pone.0118171 |
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