Violation of an Evolutionarily Conserved Immunoglobulin Diversity Gene Sequence Preference Promotes Production of dsDNA-Specific IgG Antibodies

Variability in the developing antibody repertoire is focused on the third complementarity determining region of the H chain (CDR-H3), which lies at the center of the antigen binding site where it often plays a decisive role in antigen binding. The power of VDJ recombination and N nucleotide addition...

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Detalles Bibliográficos
Autores principales: Silva-Sanchez, Aaron, Liu, Cun Ren, Vale, Andre M., Khass, Mohamed, Kapoor, Pratibha, Elgavish, Ada, Ivanov, Ivaylo I., Ippolito, Gregory C., Schelonka, Robert L., Schoeb, Trenton R., Burrows, Peter D., Schroeder, Harry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338297/
https://www.ncbi.nlm.nih.gov/pubmed/25706374
http://dx.doi.org/10.1371/journal.pone.0118171

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