Cargando…

Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes

OBJECTIVE: Leptin alleviates hyperglycemia in rodent models of Type 1 diabetes by activating leptin receptors within the central nervous system. Here we delineate whether non-canonical leptin signaling through the Creb-regulated transcriptional coactivator 1 (Crtc1) contributes to leptin-dependent i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Geun Hyang, Szabo, Andras, King, Emily M., Ayala, Jennifer, Ayala, Julio E., Altarejos, Judith Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338314/ https://www.ncbi.nlm.nih.gov/pubmed/25737949 http://dx.doi.org/10.1016/j.molmet.2014.12.006

Ejemplares similares

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
por: Sonntag, Tim, et al.
Publicado: (2018)

Leptin reverses hyperglycemia and hyperphagia in insulin deficient diabetic rats by pituitary-independent central nervous system actions
por: da Silva, Alexandre A., et al.
Publicado: (2017)

The CREB Coactivator CRTC2 Links Hepatic ER Stress and Fasting Gluconeogenesis
por: Wang, Yiguo, et al.
Publicado: (2009)

CREB-Regulated Transcriptional Coactivator 2 Proteome Landscape is Modulated by SREBF1
por: Lim, Jae Min, et al.
Publicado: (2023)

Flexible promoter architecture requirements for coactivator recruitment
por: Chiang, Derek Y, et al.
Publicado: (2006)

Coactivator Recruitment of AhR/ARNT1
por: Endler, Alexander, et al.
Publicado: (2014)

Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism
por: Xue, Yaqian, et al.
Publicado: (2023)

CREB-regulated transcription coactivator 1 enhances CREB-dependent gene expression in spinal cord to maintain the bone cancer pain in mice
por: Liang, Ying, et al.
Publicado: (2016)

The reward value of sucrose in leptin-deficient obese mice()
por: Domingos, Ana I., et al.
Publicado: (2013)

FRI069 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Weight And Associated Comorbidities In Congenital Leptin Deficiency
por: Ozsu, Elif, et al.
Publicado: (2023)

JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expression
por: Kim, Ji-Hye, et al.
Publicado: (2020)

New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity
por: Rossetti, Clara, et al.
Publicado: (2022)

Efficacy and Safety of Insulin Degludec for Hyperglycemia Management in Noncritical Hospitalized Patients with Diabetes: An Observational Study
por: Simioni, Natalino, et al.
Publicado: (2017)

The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non–small cell lung cancer
por: Rodón, Laura, et al.
Publicado: (2019)

Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH
por: Smith, Lorna I.F., et al.
Publicado: (2020)

Activation and expression of endogenous CREB‐regulated transcription coactivators (CRTC) 1, 2 and 3 in the rat adrenal gland
por: Smith, Lorna I. F., et al.
Publicado: (2020)

The Transcriptional Coactivator Cbp Interacts with β-Catenin to Activate Gene Expression
por: Takemaru, Ken-Ichi, et al.
Publicado: (2000)

Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism
por: Burgos-Ramos, Emma, et al.
Publicado: (2016)

Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity
por: Yupanqui-Lozno, Hernan, et al.
Publicado: (2019)

Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
por: German, Jonathan P., et al.
Publicado: (2010)

Zinc-responsive coactivator recruitment by the yeast Zap1 transcription factor
por: Frey, Avery G, et al.
Publicado: (2012)

BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose Production
por: Meek, Thomas H., et al.
Publicado: (2013)

Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling
por: Denroche, Heather C., et al.
Publicado: (2011)

Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)
por: García-Rodríguez, Carmen, et al.
Publicado: (1998)

Phosphorylation of CREB-Specific Coactivator CRTC2 at Ser238 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cells
por: Wang, Yi, et al.
Publicado: (2020)

Congenital leptin deficiency and thyroid function
por: Paz-Filho, Gilberto, et al.
Publicado: (2009)

Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
por: Lizcano, Fernando, et al.
Publicado: (2013)

Leptin therapy, insulin sensitivity, and glucose homeostasis
por: Paz-Filho, Gilberto, et al.
Publicado: (2012)

SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes()
por: Zampieri, Thais T., et al.
Publicado: (2014)

Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase
por: Gao, Yuanqing, et al.
Publicado: (2017)

Deregulation of CREB Signaling Pathway Induced by Chronic Hyperglycemia Downregulates NeuroD Transcription
por: Cho, In-Su, et al.
Publicado: (2012)

Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
por: Wright, Jordan J., et al.
Publicado: (2023)

Epistatic Interactions between CREB and CREM Variants in Affective Disorder
por: Chiesa, Alberto, et al.
Publicado: (2014)

Transient CREB-mediated transcription is key in direct neuronal reprogramming
por: Gascón, Sergio, et al.
Publicado: (2017)

SAT-665 A Case of Hyperglycemia in Post Pancreas Transplant Patient-Is It Insulin Deficiency or Insulin Resistance
por: Polavarapu, Preethi, et al.
Publicado: (2020)

Affinity kinetics of leptin-reactive immunoglobulins are associated with plasma leptin and markers of obesity and diabetes
por: Bouhajja, Houda, et al.
Publicado: (2018)

Leptin Receptors in RIP-Cre(25Mgn) Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice
por: Singha, Ashish, et al.
Publicado: (2020)

Pax6 Represses Androgen Receptor-Mediated Transactivation by Inhibiting Recruitment of the Coactivator SPBP
por: Elvenes, Julianne, et al.
Publicado: (2011)

Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses
por: Bolt, Michael J., et al.
Publicado: (2013)

Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer
por: Carper, Miranda B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l68rmsr7ocge30csfcjto2g0ef