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Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults
The objective of this study was to compare quinolone resistance and gyrA mutations in clinical isolates of Klebsiella pneumoniae and Escherichia coli from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial su...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338376/ https://www.ncbi.nlm.nih.gov/pubmed/25756041 http://dx.doi.org/10.1155/2015/168292 |
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author | Huang, Ying Ogutu, James O. Gu, Jiarui Ding, Fengshu You, Yuhong Huo, Yan Zhao, Hong Li, Wenjing Zhang, Zhiwei Zhang, Wenli Chen, Xiaobei Fu, Yingmei Zhang, Fengmin |
author_facet | Huang, Ying Ogutu, James O. Gu, Jiarui Ding, Fengshu You, Yuhong Huo, Yan Zhao, Hong Li, Wenjing Zhang, Zhiwei Zhang, Wenli Chen, Xiaobei Fu, Yingmei Zhang, Fengmin |
author_sort | Huang, Ying |
collection | PubMed |
description | The objective of this study was to compare quinolone resistance and gyrA mutations in clinical isolates of Klebsiella pneumoniae and Escherichia coli from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial susceptibilities of 61 isolates from children and 79 isolates from adults were determined. The mutations in the quinolone resistance-determining regions in gyrA gene were detected by PCR and DNA sequencing. Fluoroquinolone resistance and types of gyrA mutations in isolates from children and adults were compared and statistically analyzed. No significant differences were detected in the resistance rates of ciprofloxacin and levofloxacin between children and adults among isolates of the two species (all P > 0.05). The double mutation Ser83→Leu + Asp87→Asn in the ciprofloxacin-resistant isolates occurred in 73.7% isolates from the children and 67.9% from the adults, respectively (P = 0.5444). Children with no known history of quinolone administration were found to carry fluoroquinolone-resistant Enterobacteriaceae isolates. The occurrence of ciprofloxacin resistance and the major types of gyrA mutations in the isolates from the children were similar to those from adults. The results indicate that precautions should be taken on environmental issues resulting from widespread transmission of quinolone resistance. |
format | Online Article Text |
id | pubmed-4338376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43383762015-03-09 Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults Huang, Ying Ogutu, James O. Gu, Jiarui Ding, Fengshu You, Yuhong Huo, Yan Zhao, Hong Li, Wenjing Zhang, Zhiwei Zhang, Wenli Chen, Xiaobei Fu, Yingmei Zhang, Fengmin Biomed Res Int Research Article The objective of this study was to compare quinolone resistance and gyrA mutations in clinical isolates of Klebsiella pneumoniae and Escherichia coli from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial susceptibilities of 61 isolates from children and 79 isolates from adults were determined. The mutations in the quinolone resistance-determining regions in gyrA gene were detected by PCR and DNA sequencing. Fluoroquinolone resistance and types of gyrA mutations in isolates from children and adults were compared and statistically analyzed. No significant differences were detected in the resistance rates of ciprofloxacin and levofloxacin between children and adults among isolates of the two species (all P > 0.05). The double mutation Ser83→Leu + Asp87→Asn in the ciprofloxacin-resistant isolates occurred in 73.7% isolates from the children and 67.9% from the adults, respectively (P = 0.5444). Children with no known history of quinolone administration were found to carry fluoroquinolone-resistant Enterobacteriaceae isolates. The occurrence of ciprofloxacin resistance and the major types of gyrA mutations in the isolates from the children were similar to those from adults. The results indicate that precautions should be taken on environmental issues resulting from widespread transmission of quinolone resistance. Hindawi Publishing Corporation 2015 2015-02-10 /pmc/articles/PMC4338376/ /pubmed/25756041 http://dx.doi.org/10.1155/2015/168292 Text en Copyright © 2015 Ying Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Ying Ogutu, James O. Gu, Jiarui Ding, Fengshu You, Yuhong Huo, Yan Zhao, Hong Li, Wenjing Zhang, Zhiwei Zhang, Wenli Chen, Xiaobei Fu, Yingmei Zhang, Fengmin Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults |
title | Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults |
title_full | Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults |
title_fullStr | Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults |
title_full_unstemmed | Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults |
title_short | Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults |
title_sort | comparative analysis of quinolone resistance in clinical isolates of klebsiella pneumoniae and escherichia coli from chinese children and adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338376/ https://www.ncbi.nlm.nih.gov/pubmed/25756041 http://dx.doi.org/10.1155/2015/168292 |
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