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Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study

A cochlear implant (CI) is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI...

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Detalles Bibliográficos
Autores principales: Kang, Soojin, Chwodhury, Tanmoy, Moon, Il Joon, Hong, Sung Hwa, Yang, Hyejin, Won, Jong Ho, Woo, Jihwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338381/
https://www.ncbi.nlm.nih.gov/pubmed/25755675
http://dx.doi.org/10.1155/2015/934382
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author Kang, Soojin
Chwodhury, Tanmoy
Moon, Il Joon
Hong, Sung Hwa
Yang, Hyejin
Won, Jong Ho
Woo, Jihwan
author_facet Kang, Soojin
Chwodhury, Tanmoy
Moon, Il Joon
Hong, Sung Hwa
Yang, Hyejin
Won, Jong Ho
Woo, Jihwan
author_sort Kang, Soojin
collection PubMed
description A cochlear implant (CI) is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI results. This paper describes how the electrode position influences the auditory nerve fiber (ANF) response to either a single pulse or low- (250 pulses/s) and high-rate (5,000 pulses/s) pulse-trains using a computational model. The field potential in the cochlea was calculated using a three-dimensional finite-element model, and the ANF response was simulated using a biophysical ANF model. The effects were evaluated in terms of the dynamic range, stochasticity, and spike excitation pattern. The relative spread, threshold, jitter, and initiated node were analyzed for single-pulse response; and the dynamic range, threshold, initiated node, and interspike interval were analyzed for pulse-train stimuli responses. Electrode position was found to significantly affect the spatiotemporal pattern of the ANF response, and this effect was significantly dependent on the stimulus rate. We believe that these modeling results can provide guidance regarding perimodiolar and lateral insertion of CIs in clinical settings and help understand CI performance.
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spelling pubmed-43383812015-03-09 Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study Kang, Soojin Chwodhury, Tanmoy Moon, Il Joon Hong, Sung Hwa Yang, Hyejin Won, Jong Ho Woo, Jihwan Comput Math Methods Med Research Article A cochlear implant (CI) is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI results. This paper describes how the electrode position influences the auditory nerve fiber (ANF) response to either a single pulse or low- (250 pulses/s) and high-rate (5,000 pulses/s) pulse-trains using a computational model. The field potential in the cochlea was calculated using a three-dimensional finite-element model, and the ANF response was simulated using a biophysical ANF model. The effects were evaluated in terms of the dynamic range, stochasticity, and spike excitation pattern. The relative spread, threshold, jitter, and initiated node were analyzed for single-pulse response; and the dynamic range, threshold, initiated node, and interspike interval were analyzed for pulse-train stimuli responses. Electrode position was found to significantly affect the spatiotemporal pattern of the ANF response, and this effect was significantly dependent on the stimulus rate. We believe that these modeling results can provide guidance regarding perimodiolar and lateral insertion of CIs in clinical settings and help understand CI performance. Hindawi Publishing Corporation 2015 2015-02-10 /pmc/articles/PMC4338381/ /pubmed/25755675 http://dx.doi.org/10.1155/2015/934382 Text en Copyright © 2015 Soojin Kang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kang, Soojin
Chwodhury, Tanmoy
Moon, Il Joon
Hong, Sung Hwa
Yang, Hyejin
Won, Jong Ho
Woo, Jihwan
Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study
title Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study
title_full Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study
title_fullStr Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study
title_full_unstemmed Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study
title_short Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study
title_sort effects of electrode position on spatiotemporal auditory nerve fiber responses: a 3d computational model study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338381/
https://www.ncbi.nlm.nih.gov/pubmed/25755675
http://dx.doi.org/10.1155/2015/934382
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