Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

We have previously described novel histone acetyltransferase (HAT) inhibitors that block neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT inhibitors, PU139 and PU141, induce cellular histone hypoacetylation and inhibit growth of several neoplastic cell lines...

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Detalles Bibliográficos
Autores principales: Gajer, J M, Furdas, S D, Gründer, A, Gothwal, M, Heinicke, U, Keller, K, Colland, F, Fulda, S, Pahl, H L, Fichtner, I, Sippl, W, Jung, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338425/
https://www.ncbi.nlm.nih.gov/pubmed/25664930
http://dx.doi.org/10.1038/oncsis.2014.51

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