Cargando…

Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis

Published data on the associations between three well-characterized polymorphisms in the interleukin 6 and 10 (IL-6 and IL-10) genes and the risk of pneumonia are inconclusive. A meta-analysis was performed to derive a more precise estimate. The electronic databases MEDLINE (Ovid) and PubMed were se...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hong, Li, Ning, Wan, Huanying, Cheng, Qijian, Shi, Guochao, Feng, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338428/
https://www.ncbi.nlm.nih.gov/pubmed/25708204
http://dx.doi.org/10.1038/srep08559
_version_ 1782481212317630464
author Chen, Hong
Li, Ning
Wan, Huanying
Cheng, Qijian
Shi, Guochao
Feng, Yun
author_facet Chen, Hong
Li, Ning
Wan, Huanying
Cheng, Qijian
Shi, Guochao
Feng, Yun
author_sort Chen, Hong
collection PubMed
description Published data on the associations between three well-characterized polymorphisms in the interleukin 6 and 10 (IL-6 and IL-10) genes and the risk of pneumonia are inconclusive. A meta-analysis was performed to derive a more precise estimate. The electronic databases MEDLINE (Ovid) and PubMed were searched from the earliest possible year to May 2014. A total of 9 articles met the criteria, and these included 3460 patients with pneumonia and 3037 controls. The data were analyzed with RevMan software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses of the full data set failed to identify any significant association of pneumonia risk with the IL-6 gene -174C allele (OR = 1.00; 95% CI: 0.98–1.03), the IL-10 gene -592C allele (OR = 1.20; 95% CI: 0.95–1.52), or the IL-10 gene -1082A allele (OR = 1.21; 95% CI: 0.99–1.49). In a subgroup analysis by pneumonia type, ethnicity, sample size and quality score, no significantly increased risk of pneumonia was found for individuals carrying the IL-6 gene -174C allele. There was a low probability of publication bias, as reflected by the fail-safe number. This meta-analysis suggests that there is no significantly increased risk of pneumonia associated with previously reported IL-6 and IL-10 polymorphisms.
format Online
Article
Text
id pubmed-4338428
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-43384282015-03-04 Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis Chen, Hong Li, Ning Wan, Huanying Cheng, Qijian Shi, Guochao Feng, Yun Sci Rep Article Published data on the associations between three well-characterized polymorphisms in the interleukin 6 and 10 (IL-6 and IL-10) genes and the risk of pneumonia are inconclusive. A meta-analysis was performed to derive a more precise estimate. The electronic databases MEDLINE (Ovid) and PubMed were searched from the earliest possible year to May 2014. A total of 9 articles met the criteria, and these included 3460 patients with pneumonia and 3037 controls. The data were analyzed with RevMan software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses of the full data set failed to identify any significant association of pneumonia risk with the IL-6 gene -174C allele (OR = 1.00; 95% CI: 0.98–1.03), the IL-10 gene -592C allele (OR = 1.20; 95% CI: 0.95–1.52), or the IL-10 gene -1082A allele (OR = 1.21; 95% CI: 0.99–1.49). In a subgroup analysis by pneumonia type, ethnicity, sample size and quality score, no significantly increased risk of pneumonia was found for individuals carrying the IL-6 gene -174C allele. There was a low probability of publication bias, as reflected by the fail-safe number. This meta-analysis suggests that there is no significantly increased risk of pneumonia associated with previously reported IL-6 and IL-10 polymorphisms. Nature Publishing Group 2015-02-24 /pmc/articles/PMC4338428/ /pubmed/25708204 http://dx.doi.org/10.1038/srep08559 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chen, Hong
Li, Ning
Wan, Huanying
Cheng, Qijian
Shi, Guochao
Feng, Yun
Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis
title Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis
title_full Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis
title_fullStr Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis
title_full_unstemmed Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis
title_short Associations of Three Well-Characterized Polymorphisms in the IL-6 and IL-10 Genes with Pneumonia: A Meta-Analysis
title_sort associations of three well-characterized polymorphisms in the il-6 and il-10 genes with pneumonia: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338428/
https://www.ncbi.nlm.nih.gov/pubmed/25708204
http://dx.doi.org/10.1038/srep08559
work_keys_str_mv AT chenhong associationsofthreewellcharacterizedpolymorphismsintheil6andil10geneswithpneumoniaametaanalysis
AT lining associationsofthreewellcharacterizedpolymorphismsintheil6andil10geneswithpneumoniaametaanalysis
AT wanhuanying associationsofthreewellcharacterizedpolymorphismsintheil6andil10geneswithpneumoniaametaanalysis
AT chengqijian associationsofthreewellcharacterizedpolymorphismsintheil6andil10geneswithpneumoniaametaanalysis
AT shiguochao associationsofthreewellcharacterizedpolymorphismsintheil6andil10geneswithpneumoniaametaanalysis
AT fengyun associationsofthreewellcharacterizedpolymorphismsintheil6andil10geneswithpneumoniaametaanalysis