Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage

Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We show that Ym1 and Ym2 induce neutrophil accumulation through expansion of interleukin 17 (IL-17)-producing γδ...

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Detalles Bibliográficos
Autores principales: Sutherland, Tara E., Logan, Nicola, Rückerl, Dominik, Humbles, Alison A., Allan, Stuart M., Papayannopoulos, Venizelos, Stockinger, Brigitta, Maizels, Rick M., Allen, Judith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338525/
https://www.ncbi.nlm.nih.gov/pubmed/25326751
http://dx.doi.org/10.1038/ni.3023

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