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Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria

Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are protected from mosquito bites. Here, we identify the presence of antibiotics in the blood of malaria-infected people as a new risk of increasing dis...

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Autores principales: Gendrin, Mathilde, Rodgers, Faye H., Yerbanga, Rakiswendé S., Ouédraogo, Jean Bosco, Basáñez, María-Gloria, Cohuet, Anna, Christophides, George K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338536/
https://www.ncbi.nlm.nih.gov/pubmed/25562286
http://dx.doi.org/10.1038/ncomms6921
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author Gendrin, Mathilde
Rodgers, Faye H.
Yerbanga, Rakiswendé S.
Ouédraogo, Jean Bosco
Basáñez, María-Gloria
Cohuet, Anna
Christophides, George K.
author_facet Gendrin, Mathilde
Rodgers, Faye H.
Yerbanga, Rakiswendé S.
Ouédraogo, Jean Bosco
Basáñez, María-Gloria
Cohuet, Anna
Christophides, George K.
author_sort Gendrin, Mathilde
collection PubMed
description Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are protected from mosquito bites. Here, we identify the presence of antibiotics in the blood of malaria-infected people as a new risk of increasing disease transmission. We show that antibiotics in ingested blood enhance the susceptibility of Anopheles gambiae mosquitoes to malaria infection by disturbing their gut microbiota. This effect is confirmed in a semi-natural setting by feeding mosquitoes with blood of children naturally infected with Plasmodium falciparum. Antibiotic exposure additionally increases mosquito survival and fecundity, which are known to augment vectorial capacity. These findings suggest that malaria transmission may be exacerbated in areas of high antibiotic usage, and that regions targeted by mass drug administration programs against communicable diseases may necessitate increased vector control.
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spelling pubmed-43385362015-03-20 Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria Gendrin, Mathilde Rodgers, Faye H. Yerbanga, Rakiswendé S. Ouédraogo, Jean Bosco Basáñez, María-Gloria Cohuet, Anna Christophides, George K. Nat Commun Article Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are protected from mosquito bites. Here, we identify the presence of antibiotics in the blood of malaria-infected people as a new risk of increasing disease transmission. We show that antibiotics in ingested blood enhance the susceptibility of Anopheles gambiae mosquitoes to malaria infection by disturbing their gut microbiota. This effect is confirmed in a semi-natural setting by feeding mosquitoes with blood of children naturally infected with Plasmodium falciparum. Antibiotic exposure additionally increases mosquito survival and fecundity, which are known to augment vectorial capacity. These findings suggest that malaria transmission may be exacerbated in areas of high antibiotic usage, and that regions targeted by mass drug administration programs against communicable diseases may necessitate increased vector control. Nature Pub. Group 2015-01-06 /pmc/articles/PMC4338536/ /pubmed/25562286 http://dx.doi.org/10.1038/ncomms6921 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Gendrin, Mathilde
Rodgers, Faye H.
Yerbanga, Rakiswendé S.
Ouédraogo, Jean Bosco
Basáñez, María-Gloria
Cohuet, Anna
Christophides, George K.
Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
title Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
title_full Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
title_fullStr Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
title_full_unstemmed Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
title_short Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
title_sort antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338536/
https://www.ncbi.nlm.nih.gov/pubmed/25562286
http://dx.doi.org/10.1038/ncomms6921
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