Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems

BACKGROUND: Antibodies raised against selected antigens over-expressed at the cell surface of malignant cells have been chemically conjugated to protein toxin domains to obtain immunotoxins (ITs) able to selectively kill cancer cells. Since latest generation immunotoxins are composed of a toxic doma...

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Detalles Bibliográficos
Autores principales: Della Cristina, Pietro, Castagna, Monica, Lombardi, Alessio, Barison, Erika, Tagliabue, Giovanni, Ceriotti, Aldo, Koutris, Ilias, Di Leandro, Luana, Giansanti, Francesco, Vago, Riccardo, Ippoliti, Rodolfo, Flavell, Sopsamorn U, Flavell, David J, Colombatti, Marco, Fabbrini, Maria Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338634/
https://www.ncbi.nlm.nih.gov/pubmed/25889802
http://dx.doi.org/10.1186/s12934-015-0202-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338634/
https://www.ncbi.nlm.nih.gov/pubmed/25889802
http://dx.doi.org/10.1186/s12934-015-0202-z

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