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Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat

BACKGROUND: Upper body subcutaneous neck fat (UBSF) is a unique fat depot anatomically separate from visceral abdominal fat that appears to be associated with cardiometabolic risk above and beyond generalized adiposity. We sought to develop a protocol to quantify UBSF using multidetector computed to...

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Autores principales: Rosenquist, Klara J., Therkelsen, Kate E., Massaro, Joseph M., Hoffmann, Udo, Fox, Caroline S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338686/
https://www.ncbi.nlm.nih.gov/pubmed/25523152
http://dx.doi.org/10.1161/JAHA.114.000979
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author Rosenquist, Klara J.
Therkelsen, Kate E.
Massaro, Joseph M.
Hoffmann, Udo
Fox, Caroline S.
author_facet Rosenquist, Klara J.
Therkelsen, Kate E.
Massaro, Joseph M.
Hoffmann, Udo
Fox, Caroline S.
author_sort Rosenquist, Klara J.
collection PubMed
description BACKGROUND: Upper body subcutaneous neck fat (UBSF) is a unique fat depot anatomically separate from visceral abdominal fat that appears to be associated with cardiometabolic risk above and beyond generalized adiposity. We sought to develop a protocol to quantify UBSF using multidetector computed tomography measurements. METHODS AND RESULTS: Protocol development was performed in participants from the Framingham Heart Study who had participated in the multidetector computed tomography scanning substudy, consisting of chest scans. Volumetric assessment of UBSF was defined by 40 contiguous 0.625‐mm slices superior to the body of the sternum. The reader manually traced the chest to identify total neck fat. Breast tissue exterior to the chest wall was excluded. Subcutaneous and visceral fat volumes were obtained using standard protocols. Age‐ and sex‐adjusted Pearson correlation coefficients were used to assess the association among UBSF, traditional adiposity measures, and cardiometabolic risk factors. Inter‐ and intrareader reproducibility was assessed using intraclass correlation coefficients. Volumetric assessments were obtained in 92 participants because 8 scans were not readable (51% women; mean age: 59 years [women], 58 years [men]). The mean volume of UBSF was 310 cm(3) for women and 345 cm(3) for men. Intra‐ and interreader class correlation coefficients were 0.99 and 0.99, respectively. UBSF was correlated with waist circumference (r=0.90), neck circumference (r=0.75), body mass index (r=0.89), subcutaneous adipose tissue (r=0.87), and visceral adipose tissue (r=0.86). CONCLUSIONS: UBSF can be quantified reproducibly using computed tomography in a community‐dwelling sample from the Framingham Heart Study.
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spelling pubmed-43386862015-02-27 Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat Rosenquist, Klara J. Therkelsen, Kate E. Massaro, Joseph M. Hoffmann, Udo Fox, Caroline S. J Am Heart Assoc Original Research BACKGROUND: Upper body subcutaneous neck fat (UBSF) is a unique fat depot anatomically separate from visceral abdominal fat that appears to be associated with cardiometabolic risk above and beyond generalized adiposity. We sought to develop a protocol to quantify UBSF using multidetector computed tomography measurements. METHODS AND RESULTS: Protocol development was performed in participants from the Framingham Heart Study who had participated in the multidetector computed tomography scanning substudy, consisting of chest scans. Volumetric assessment of UBSF was defined by 40 contiguous 0.625‐mm slices superior to the body of the sternum. The reader manually traced the chest to identify total neck fat. Breast tissue exterior to the chest wall was excluded. Subcutaneous and visceral fat volumes were obtained using standard protocols. Age‐ and sex‐adjusted Pearson correlation coefficients were used to assess the association among UBSF, traditional adiposity measures, and cardiometabolic risk factors. Inter‐ and intrareader reproducibility was assessed using intraclass correlation coefficients. Volumetric assessments were obtained in 92 participants because 8 scans were not readable (51% women; mean age: 59 years [women], 58 years [men]). The mean volume of UBSF was 310 cm(3) for women and 345 cm(3) for men. Intra‐ and interreader class correlation coefficients were 0.99 and 0.99, respectively. UBSF was correlated with waist circumference (r=0.90), neck circumference (r=0.75), body mass index (r=0.89), subcutaneous adipose tissue (r=0.87), and visceral adipose tissue (r=0.86). CONCLUSIONS: UBSF can be quantified reproducibly using computed tomography in a community‐dwelling sample from the Framingham Heart Study. Blackwell Publishing Ltd 2014-12-18 /pmc/articles/PMC4338686/ /pubmed/25523152 http://dx.doi.org/10.1161/JAHA.114.000979 Text en © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Rosenquist, Klara J.
Therkelsen, Kate E.
Massaro, Joseph M.
Hoffmann, Udo
Fox, Caroline S.
Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat
title Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat
title_full Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat
title_fullStr Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat
title_full_unstemmed Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat
title_short Development and Reproducibility of a Computed Tomography–Based Measurement for Upper Body Subcutaneous Neck Fat
title_sort development and reproducibility of a computed tomography–based measurement for upper body subcutaneous neck fat
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338686/
https://www.ncbi.nlm.nih.gov/pubmed/25523152
http://dx.doi.org/10.1161/JAHA.114.000979
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