Pharmacological Inhibitor of Notch Signaling Stabilizes the Progression of Small Abdominal Aortic Aneurysm in a Mouse Model

BACKGROUND: The progression of abdominal aortic aneurysm (AAA) involves a sustained influx of proinflammatory macrophages, which exacerbate tissue injury by releasing cytokines, chemokines, and matrix metalloproteinases. Previously, we showed that Notch deficiency reduces the development of AAA in t...

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Detalles Bibliográficos
Autores principales: Cheng, Jeeyun, Koenig, Sara N., Kuivaniemi, Helena S., Garg, Vidu, Hans, Chetan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338693/
https://www.ncbi.nlm.nih.gov/pubmed/25349182
http://dx.doi.org/10.1161/JAHA.114.001064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338693/
https://www.ncbi.nlm.nih.gov/pubmed/25349182
http://dx.doi.org/10.1161/JAHA.114.001064

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