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Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans

BACKGROUND: Epidemiologic evidence suggests a link between short sleep duration and cardiovascular risk, although the nature of any relationship and mechanisms remain unclear. Short sleep duration has also been linked to an increase in cardiovascular events. Endothelial dysfunction has itself been i...

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Autores principales: Calvin, Andrew D., Covassin, Naima, Kremers, Walter K., Adachi, Taro, Macedo, Paula, Albuquerque, Felipe N., Bukartyk, Jan, Davison, Diane E., Levine, James A., Singh, Prachi, Wang, Shihan, Somers, Virend K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338700/
https://www.ncbi.nlm.nih.gov/pubmed/25424573
http://dx.doi.org/10.1161/JAHA.114.001143
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author Calvin, Andrew D.
Covassin, Naima
Kremers, Walter K.
Adachi, Taro
Macedo, Paula
Albuquerque, Felipe N.
Bukartyk, Jan
Davison, Diane E.
Levine, James A.
Singh, Prachi
Wang, Shihan
Somers, Virend K.
author_facet Calvin, Andrew D.
Covassin, Naima
Kremers, Walter K.
Adachi, Taro
Macedo, Paula
Albuquerque, Felipe N.
Bukartyk, Jan
Davison, Diane E.
Levine, James A.
Singh, Prachi
Wang, Shihan
Somers, Virend K.
author_sort Calvin, Andrew D.
collection PubMed
description BACKGROUND: Epidemiologic evidence suggests a link between short sleep duration and cardiovascular risk, although the nature of any relationship and mechanisms remain unclear. Short sleep duration has also been linked to an increase in cardiovascular events. Endothelial dysfunction has itself been implicated as a mediator of heightened cardiovascular risk. We sought to determine the effect of 8 days/8 nights of partial sleep restriction on endothelial function in healthy humans. METHODS AND RESULTS: Sixteen healthy volunteers underwent a randomized study of usual sleep versus sleep restriction of two‐thirds normal sleep time for 8 days/8 nights in a hospital‐based clinical research unit. The main outcome was endothelial function measured by flow‐mediated brachial artery vasodilatation (FMD). Those randomized to sleep restriction slept 5.1 hours/night during the experimental period compared with 6.9 hours/night in the control group. Sleep restriction was associated with significant impairment in FMD (8.6±4.6% during the initial pre‐randomization acclimation phase versus 5.2±3.4% during the randomized experimental phase, P=0.01) whereas no change was seen in the control group (5.0±3.0 during the acclimation phase versus 6.73±2.9% during the experimental phase, P=0.10) for a between‐groups difference of −4.40% (95% CI −7.00 to −1.81%, P=0.003). No change was seen in non‐flow mediated vasodilatation (NFMD) in either group. CONCLUSION: In healthy individuals, moderate sleep restriction causes endothelial dysfunction. CLINICAL TRIAL REGISTRATION: URL: ClinicalTrials.gov. Unique identifier: NCT01334788.
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spelling pubmed-43387002015-02-27 Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans Calvin, Andrew D. Covassin, Naima Kremers, Walter K. Adachi, Taro Macedo, Paula Albuquerque, Felipe N. Bukartyk, Jan Davison, Diane E. Levine, James A. Singh, Prachi Wang, Shihan Somers, Virend K. J Am Heart Assoc Original Research BACKGROUND: Epidemiologic evidence suggests a link between short sleep duration and cardiovascular risk, although the nature of any relationship and mechanisms remain unclear. Short sleep duration has also been linked to an increase in cardiovascular events. Endothelial dysfunction has itself been implicated as a mediator of heightened cardiovascular risk. We sought to determine the effect of 8 days/8 nights of partial sleep restriction on endothelial function in healthy humans. METHODS AND RESULTS: Sixteen healthy volunteers underwent a randomized study of usual sleep versus sleep restriction of two‐thirds normal sleep time for 8 days/8 nights in a hospital‐based clinical research unit. The main outcome was endothelial function measured by flow‐mediated brachial artery vasodilatation (FMD). Those randomized to sleep restriction slept 5.1 hours/night during the experimental period compared with 6.9 hours/night in the control group. Sleep restriction was associated with significant impairment in FMD (8.6±4.6% during the initial pre‐randomization acclimation phase versus 5.2±3.4% during the randomized experimental phase, P=0.01) whereas no change was seen in the control group (5.0±3.0 during the acclimation phase versus 6.73±2.9% during the experimental phase, P=0.10) for a between‐groups difference of −4.40% (95% CI −7.00 to −1.81%, P=0.003). No change was seen in non‐flow mediated vasodilatation (NFMD) in either group. CONCLUSION: In healthy individuals, moderate sleep restriction causes endothelial dysfunction. CLINICAL TRIAL REGISTRATION: URL: ClinicalTrials.gov. Unique identifier: NCT01334788. Blackwell Publishing Ltd 2014-11-25 /pmc/articles/PMC4338700/ /pubmed/25424573 http://dx.doi.org/10.1161/JAHA.114.001143 Text en © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Calvin, Andrew D.
Covassin, Naima
Kremers, Walter K.
Adachi, Taro
Macedo, Paula
Albuquerque, Felipe N.
Bukartyk, Jan
Davison, Diane E.
Levine, James A.
Singh, Prachi
Wang, Shihan
Somers, Virend K.
Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans
title Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans
title_full Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans
title_fullStr Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans
title_full_unstemmed Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans
title_short Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans
title_sort experimental sleep restriction causes endothelial dysfunction in healthy humans
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338700/
https://www.ncbi.nlm.nih.gov/pubmed/25424573
http://dx.doi.org/10.1161/JAHA.114.001143
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