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Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure
BACKGROUND: Renal impairment is a common comorbidity and the strongest risk factor for poor prognosis in acute decompensated heart failure (ADHF). In clinical practice, renal function is labile during episodes of ADHF, and often worsens after discharge. The significance of worsening of renal functio...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338704/ https://www.ncbi.nlm.nih.gov/pubmed/25370599 http://dx.doi.org/10.1161/JAHA.114.001174 |
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author | Ueda, Tomoya Kawakami, Rika Sugawara, Yu Okada, Sadanori Nishida, Taku Onoue, Kenji Soeda, Tsunenari Okayama, Satoshi Takeda, Yukiji Watanabe, Makoto Kawata, Hiroyuki Uemura, Shiro Saito, Yoshihiko |
author_facet | Ueda, Tomoya Kawakami, Rika Sugawara, Yu Okada, Sadanori Nishida, Taku Onoue, Kenji Soeda, Tsunenari Okayama, Satoshi Takeda, Yukiji Watanabe, Makoto Kawata, Hiroyuki Uemura, Shiro Saito, Yoshihiko |
author_sort | Ueda, Tomoya |
collection | PubMed |
description | BACKGROUND: Renal impairment is a common comorbidity and the strongest risk factor for poor prognosis in acute decompensated heart failure (ADHF). In clinical practice, renal function is labile during episodes of ADHF, and often worsens after discharge. The significance of worsening of renal function (WRF) after discharge has not been investigated as extensively as baseline renal function at admission or WRF during hospitalization. METHODS AND RESULTS: Among 611 consecutive patients with ADHF emergently admitted to our hospital, 233 patients with 3 measurements of serum creatinine (SCr) level measurements (on admission, at discharge, and 1 year after discharge) were included in the present study. Patients were divided into 2 groups according to the presence or absence of WRF at 1 year after discharge (1y‐WRF), defined as an absolute increase in SCr >0.3 mg/dL (>26.5 μmol/L) plus a ≥25% increase in SCr at 1 year after discharge compared to the SCr value at discharge. All‐cause and cardiovascular mortality were assessed as adverse outcomes. During a mean follow‐up of 35.4 months, 1y‐WRF occurred in 48 of 233 patients. There were 66 deaths from all causes. All‐cause and cardiovascular mortality were significantly higher in patients with 1y‐WRF (log‐rank P<0.0001 and P<0.0001, respectively) according to Kaplan–Meier analysis. In a multivariate Cox proportional hazards model, 1y‐WRF was a strong and independent predictor of all‐cause and cardiovascular mortality. Hemoglobin and B‐type natriuretic peptide at discharge, as well as left ventricular ejection fraction <50%, were independent predictors of 1y‐WRF. CONCLUSIONS: In patients with ADHF, 1y‐WRF is a strong predictor of all‐cause and cardiovascular mortality. |
format | Online Article Text |
id | pubmed-4338704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43387042015-02-27 Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure Ueda, Tomoya Kawakami, Rika Sugawara, Yu Okada, Sadanori Nishida, Taku Onoue, Kenji Soeda, Tsunenari Okayama, Satoshi Takeda, Yukiji Watanabe, Makoto Kawata, Hiroyuki Uemura, Shiro Saito, Yoshihiko J Am Heart Assoc Original Research BACKGROUND: Renal impairment is a common comorbidity and the strongest risk factor for poor prognosis in acute decompensated heart failure (ADHF). In clinical practice, renal function is labile during episodes of ADHF, and often worsens after discharge. The significance of worsening of renal function (WRF) after discharge has not been investigated as extensively as baseline renal function at admission or WRF during hospitalization. METHODS AND RESULTS: Among 611 consecutive patients with ADHF emergently admitted to our hospital, 233 patients with 3 measurements of serum creatinine (SCr) level measurements (on admission, at discharge, and 1 year after discharge) were included in the present study. Patients were divided into 2 groups according to the presence or absence of WRF at 1 year after discharge (1y‐WRF), defined as an absolute increase in SCr >0.3 mg/dL (>26.5 μmol/L) plus a ≥25% increase in SCr at 1 year after discharge compared to the SCr value at discharge. All‐cause and cardiovascular mortality were assessed as adverse outcomes. During a mean follow‐up of 35.4 months, 1y‐WRF occurred in 48 of 233 patients. There were 66 deaths from all causes. All‐cause and cardiovascular mortality were significantly higher in patients with 1y‐WRF (log‐rank P<0.0001 and P<0.0001, respectively) according to Kaplan–Meier analysis. In a multivariate Cox proportional hazards model, 1y‐WRF was a strong and independent predictor of all‐cause and cardiovascular mortality. Hemoglobin and B‐type natriuretic peptide at discharge, as well as left ventricular ejection fraction <50%, were independent predictors of 1y‐WRF. CONCLUSIONS: In patients with ADHF, 1y‐WRF is a strong predictor of all‐cause and cardiovascular mortality. Blackwell Publishing Ltd 2014-11-04 /pmc/articles/PMC4338704/ /pubmed/25370599 http://dx.doi.org/10.1161/JAHA.114.001174 Text en © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Ueda, Tomoya Kawakami, Rika Sugawara, Yu Okada, Sadanori Nishida, Taku Onoue, Kenji Soeda, Tsunenari Okayama, Satoshi Takeda, Yukiji Watanabe, Makoto Kawata, Hiroyuki Uemura, Shiro Saito, Yoshihiko Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure |
title | Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure |
title_full | Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure |
title_fullStr | Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure |
title_full_unstemmed | Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure |
title_short | Worsening of Renal Function During 1 Year After Hospital Discharge Is a Strong and Independent Predictor of All‐Cause Mortality in Acute Decompensated Heart Failure |
title_sort | worsening of renal function during 1 year after hospital discharge is a strong and independent predictor of all‐cause mortality in acute decompensated heart failure |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338704/ https://www.ncbi.nlm.nih.gov/pubmed/25370599 http://dx.doi.org/10.1161/JAHA.114.001174 |
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