Loss of Function in Heparan Sulfate Elongation Genes EXT1 and EXT 2 Results in Improved Nitric Oxide Bioavailability and Endothelial Function

BACKGROUND: Heparanase is the major enzyme involved in degradation of endothelial heparan sulfates, which is associated with impaired endothelial nitric oxide synthesis. However, the effect of heparan sulfate chain length in relation to endothelial function and nitric oxide availability has never be...

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Detalles Bibliográficos
Autores principales: Mooij, H. L., Cabrales, P., Bernelot Moens, S. J., Xu, D., Udayappan, S. D., Tsai, A. G., van der Sande, M. A. J., de Groot, E., Intaglietta, M., Kastelein, J. J. P., Dallinga‐Thie, G. M., Esko, J. D., Stroes, E. S., Nieuwdorp, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338717/
https://www.ncbi.nlm.nih.gov/pubmed/25468659
http://dx.doi.org/10.1161/JAHA.114.001274

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