Cargando…
Longitudinal and Circumferential Strain of the Proximal Aorta
BACKGROUND: Accurate assessment of mechanical properties of the proximal aorta is a requisite first step for elucidating the pathophysiology of isolated systolic hypertension. During systole, substantial proximal aortic axial displacement produces longitudinal strain, which we hypothesize causes var...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338743/ https://www.ncbi.nlm.nih.gov/pubmed/25523153 http://dx.doi.org/10.1161/JAHA.114.001536 |
_version_ | 1782358797587578880 |
---|---|
author | Bell, Vanessa Mitchell, William A. Sigurðsson, Sigurður Westenberg, Jos J. M. Gotal, John D. Torjesen, Alyssa A. Aspelund, Thor Launer, Lenore J. de Roos, Albert Gudnason, Vilmundur Harris, Tamara B. Mitchell, Gary F. |
author_facet | Bell, Vanessa Mitchell, William A. Sigurðsson, Sigurður Westenberg, Jos J. M. Gotal, John D. Torjesen, Alyssa A. Aspelund, Thor Launer, Lenore J. de Roos, Albert Gudnason, Vilmundur Harris, Tamara B. Mitchell, Gary F. |
author_sort | Bell, Vanessa |
collection | PubMed |
description | BACKGROUND: Accurate assessment of mechanical properties of the proximal aorta is a requisite first step for elucidating the pathophysiology of isolated systolic hypertension. During systole, substantial proximal aortic axial displacement produces longitudinal strain, which we hypothesize causes variable underestimation of ascending aortic circumferential strain compared to values in the longitudinally constrained descending aorta. METHODS AND RESULTS: To assess effects of longitudinal strain, we performed magnetic resonance imaging in 375 participants (72 to 94 years old, 204 women) in the Age, Gene/Environment Susceptibility‐Reykjavik Study and measured aortic circumferential and longitudinal strain. Circumferential ascending aortic area strain uncorrected for longitudinal strain was comparable in women and men (mean [95% CI], 8.3 [7.8, 8.9] versus 7.9 [7.4, 8.5]%, respectively, P=0.3). However, longitudinal strain was greater in women (8.5±2.5 versus 7.0±2.5%, P<0.001), resulting in greater longitudinally corrected circumferential ascending aortic strain (14.4 [13.6, 15.2] versus 13.0 [12.4, 13.7]%, P=0.010). Observed circumferential descending aortic strain, which did not require correction (women: 14.0 [13.2, 14.8], men: 12.4 [11.6, 13.2]%, P=0.005), was larger than uncorrected (P<0.001), but comparable to longitudinally corrected (P=0.12) circumferential ascending aortic strain. Carotid‐femoral pulse wave velocity did not correlate with uncorrected ascending aortic strain (R=−0.04, P=0.5), but was inversely related to longitudinally corrected ascending and observed descending aortic strain (R=−0.15, P=0.004; R=−0.36, P<0.001, respectively). Longitudinal strain was also inversely related to carotid‐femoral pulse wave velocity and other risk factors for higher aortic stiffness including treated hypertension. CONCLUSIONS: Longitudinal strain creates substantial and variable errors in circumferential ascending aortic area strain measurements, particularly in women, and should be considered to avoid misclassification of ascending aortic stiffness. |
format | Online Article Text |
id | pubmed-4338743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43387432015-02-27 Longitudinal and Circumferential Strain of the Proximal Aorta Bell, Vanessa Mitchell, William A. Sigurðsson, Sigurður Westenberg, Jos J. M. Gotal, John D. Torjesen, Alyssa A. Aspelund, Thor Launer, Lenore J. de Roos, Albert Gudnason, Vilmundur Harris, Tamara B. Mitchell, Gary F. J Am Heart Assoc Original Research BACKGROUND: Accurate assessment of mechanical properties of the proximal aorta is a requisite first step for elucidating the pathophysiology of isolated systolic hypertension. During systole, substantial proximal aortic axial displacement produces longitudinal strain, which we hypothesize causes variable underestimation of ascending aortic circumferential strain compared to values in the longitudinally constrained descending aorta. METHODS AND RESULTS: To assess effects of longitudinal strain, we performed magnetic resonance imaging in 375 participants (72 to 94 years old, 204 women) in the Age, Gene/Environment Susceptibility‐Reykjavik Study and measured aortic circumferential and longitudinal strain. Circumferential ascending aortic area strain uncorrected for longitudinal strain was comparable in women and men (mean [95% CI], 8.3 [7.8, 8.9] versus 7.9 [7.4, 8.5]%, respectively, P=0.3). However, longitudinal strain was greater in women (8.5±2.5 versus 7.0±2.5%, P<0.001), resulting in greater longitudinally corrected circumferential ascending aortic strain (14.4 [13.6, 15.2] versus 13.0 [12.4, 13.7]%, P=0.010). Observed circumferential descending aortic strain, which did not require correction (women: 14.0 [13.2, 14.8], men: 12.4 [11.6, 13.2]%, P=0.005), was larger than uncorrected (P<0.001), but comparable to longitudinally corrected (P=0.12) circumferential ascending aortic strain. Carotid‐femoral pulse wave velocity did not correlate with uncorrected ascending aortic strain (R=−0.04, P=0.5), but was inversely related to longitudinally corrected ascending and observed descending aortic strain (R=−0.15, P=0.004; R=−0.36, P<0.001, respectively). Longitudinal strain was also inversely related to carotid‐femoral pulse wave velocity and other risk factors for higher aortic stiffness including treated hypertension. CONCLUSIONS: Longitudinal strain creates substantial and variable errors in circumferential ascending aortic area strain measurements, particularly in women, and should be considered to avoid misclassification of ascending aortic stiffness. Blackwell Publishing Ltd 2014-12-18 /pmc/articles/PMC4338743/ /pubmed/25523153 http://dx.doi.org/10.1161/JAHA.114.001536 Text en © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Bell, Vanessa Mitchell, William A. Sigurðsson, Sigurður Westenberg, Jos J. M. Gotal, John D. Torjesen, Alyssa A. Aspelund, Thor Launer, Lenore J. de Roos, Albert Gudnason, Vilmundur Harris, Tamara B. Mitchell, Gary F. Longitudinal and Circumferential Strain of the Proximal Aorta |
title | Longitudinal and Circumferential Strain of the Proximal Aorta |
title_full | Longitudinal and Circumferential Strain of the Proximal Aorta |
title_fullStr | Longitudinal and Circumferential Strain of the Proximal Aorta |
title_full_unstemmed | Longitudinal and Circumferential Strain of the Proximal Aorta |
title_short | Longitudinal and Circumferential Strain of the Proximal Aorta |
title_sort | longitudinal and circumferential strain of the proximal aorta |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338743/ https://www.ncbi.nlm.nih.gov/pubmed/25523153 http://dx.doi.org/10.1161/JAHA.114.001536 |
work_keys_str_mv | AT bellvanessa longitudinalandcircumferentialstrainoftheproximalaorta AT mitchellwilliama longitudinalandcircumferentialstrainoftheproximalaorta AT sigurðssonsigurður longitudinalandcircumferentialstrainoftheproximalaorta AT westenbergjosjm longitudinalandcircumferentialstrainoftheproximalaorta AT gotaljohnd longitudinalandcircumferentialstrainoftheproximalaorta AT torjesenalyssaa longitudinalandcircumferentialstrainoftheproximalaorta AT aspelundthor longitudinalandcircumferentialstrainoftheproximalaorta AT launerlenorej longitudinalandcircumferentialstrainoftheproximalaorta AT deroosalbert longitudinalandcircumferentialstrainoftheproximalaorta AT gudnasonvilmundur longitudinalandcircumferentialstrainoftheproximalaorta AT harristamarab longitudinalandcircumferentialstrainoftheproximalaorta AT mitchellgaryf longitudinalandcircumferentialstrainoftheproximalaorta |