The avascular zone and neuronal remodeling of the fovea in Parkinson disease

Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons....

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Autores principales: Miri, Shahnaz, Shrier, Eric M, Glazman, Sofya, Ding, Yin, Selesnick, Ivan, Kozlowski, Piotr B, Bodis-Wollner, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338959/
https://www.ncbi.nlm.nih.gov/pubmed/25750923
http://dx.doi.org/10.1002/acn3.146
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author Miri, Shahnaz
Shrier, Eric M
Glazman, Sofya
Ding, Yin
Selesnick, Ivan
Kozlowski, Piotr B
Bodis-Wollner, Ivan
author_facet Miri, Shahnaz
Shrier, Eric M
Glazman, Sofya
Ding, Yin
Selesnick, Ivan
Kozlowski, Piotr B
Bodis-Wollner, Ivan
author_sort Miri, Shahnaz
collection PubMed
description Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers.
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spelling pubmed-43389592015-03-06 The avascular zone and neuronal remodeling of the fovea in Parkinson disease Miri, Shahnaz Shrier, Eric M Glazman, Sofya Ding, Yin Selesnick, Ivan Kozlowski, Piotr B Bodis-Wollner, Ivan Ann Clin Transl Neurol Brief Communications Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers. BlackWell Publishing Ltd 2015-02 2015-01-08 /pmc/articles/PMC4338959/ /pubmed/25750923 http://dx.doi.org/10.1002/acn3.146 Text en © 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Miri, Shahnaz
Shrier, Eric M
Glazman, Sofya
Ding, Yin
Selesnick, Ivan
Kozlowski, Piotr B
Bodis-Wollner, Ivan
The avascular zone and neuronal remodeling of the fovea in Parkinson disease
title The avascular zone and neuronal remodeling of the fovea in Parkinson disease
title_full The avascular zone and neuronal remodeling of the fovea in Parkinson disease
title_fullStr The avascular zone and neuronal remodeling of the fovea in Parkinson disease
title_full_unstemmed The avascular zone and neuronal remodeling of the fovea in Parkinson disease
title_short The avascular zone and neuronal remodeling of the fovea in Parkinson disease
title_sort avascular zone and neuronal remodeling of the fovea in parkinson disease
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338959/
https://www.ncbi.nlm.nih.gov/pubmed/25750923
http://dx.doi.org/10.1002/acn3.146
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