Cuprizone does not induce CNS demyelination in nonhuman primates

Cognitive decline is a common symptom in multiple sclerosis patients, with profound effects on the quality of life. A nonhuman primate model of multiple sclerosis would be best suited to test the effects of demyelination on complex cognitive functions such as learning and reasoning. Cuprizone has be...

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Autores principales: Chen, Zhihong, Chen, Jacqueline T, Johnson, Matthew, Gossman, Zachary C, Hendrickson, Megan, Sakaie, Ken, Martinez-Rubio, Clarissa, Gale, John T, Trapp, Bruce D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338961/
https://www.ncbi.nlm.nih.gov/pubmed/25750925
http://dx.doi.org/10.1002/acn3.159
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author Chen, Zhihong
Chen, Jacqueline T
Johnson, Matthew
Gossman, Zachary C
Hendrickson, Megan
Sakaie, Ken
Martinez-Rubio, Clarissa
Gale, John T
Trapp, Bruce D
author_facet Chen, Zhihong
Chen, Jacqueline T
Johnson, Matthew
Gossman, Zachary C
Hendrickson, Megan
Sakaie, Ken
Martinez-Rubio, Clarissa
Gale, John T
Trapp, Bruce D
author_sort Chen, Zhihong
collection PubMed
description Cognitive decline is a common symptom in multiple sclerosis patients, with profound effects on the quality of life. A nonhuman primate model of multiple sclerosis would be best suited to test the effects of demyelination on complex cognitive functions such as learning and reasoning. Cuprizone has been shown to reliably induce brain demyelination in mice. To establish a nonhuman primate model of multiple sclerosis, young adult cynomolgus monkeys were administered cuprizone per os as a dietary supplement. The subjects received increasing cuprizone doses (0.3–3% of diet) for up to 18 weeks. Magnetic resonance imaging and immunohistological analyses did not reveal demyelination in these monkeys.
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spelling pubmed-43389612015-03-06 Cuprizone does not induce CNS demyelination in nonhuman primates Chen, Zhihong Chen, Jacqueline T Johnson, Matthew Gossman, Zachary C Hendrickson, Megan Sakaie, Ken Martinez-Rubio, Clarissa Gale, John T Trapp, Bruce D Ann Clin Transl Neurol Brief Communications Cognitive decline is a common symptom in multiple sclerosis patients, with profound effects on the quality of life. A nonhuman primate model of multiple sclerosis would be best suited to test the effects of demyelination on complex cognitive functions such as learning and reasoning. Cuprizone has been shown to reliably induce brain demyelination in mice. To establish a nonhuman primate model of multiple sclerosis, young adult cynomolgus monkeys were administered cuprizone per os as a dietary supplement. The subjects received increasing cuprizone doses (0.3–3% of diet) for up to 18 weeks. Magnetic resonance imaging and immunohistological analyses did not reveal demyelination in these monkeys. BlackWell Publishing Ltd 2015-02 2014-12-18 /pmc/articles/PMC4338961/ /pubmed/25750925 http://dx.doi.org/10.1002/acn3.159 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Chen, Zhihong
Chen, Jacqueline T
Johnson, Matthew
Gossman, Zachary C
Hendrickson, Megan
Sakaie, Ken
Martinez-Rubio, Clarissa
Gale, John T
Trapp, Bruce D
Cuprizone does not induce CNS demyelination in nonhuman primates
title Cuprizone does not induce CNS demyelination in nonhuman primates
title_full Cuprizone does not induce CNS demyelination in nonhuman primates
title_fullStr Cuprizone does not induce CNS demyelination in nonhuman primates
title_full_unstemmed Cuprizone does not induce CNS demyelination in nonhuman primates
title_short Cuprizone does not induce CNS demyelination in nonhuman primates
title_sort cuprizone does not induce cns demyelination in nonhuman primates
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338961/
https://www.ncbi.nlm.nih.gov/pubmed/25750925
http://dx.doi.org/10.1002/acn3.159
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