Cargando…
Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) can result in peptic ulcer disease (PUD) which is a common condition worldwide. The aim of this study was to evaluate the antiulcer properties of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone) (HPTP) chalcone in rats using indomethacin as ulcero...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339009/ https://www.ncbi.nlm.nih.gov/pubmed/25551777 http://dx.doi.org/10.1186/s12917-014-0303-7 |
_version_ | 1782358832302784512 |
---|---|
author | Dhiyaaldeen, Summaya M Amin, Zahra A Darvish, Pouya H Mustafa, Iman Fahmi Jamil, Mazen M Rouhollahi, Elham Abdulla, Mahmood A |
author_facet | Dhiyaaldeen, Summaya M Amin, Zahra A Darvish, Pouya H Mustafa, Iman Fahmi Jamil, Mazen M Rouhollahi, Elham Abdulla, Mahmood A |
author_sort | Dhiyaaldeen, Summaya M |
collection | PubMed |
description | BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) can result in peptic ulcer disease (PUD) which is a common condition worldwide. The aim of this study was to evaluate the antiulcer properties of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone) (HPTP) chalcone in rats using indomethacin as ulcerogenic agent. RESULTS: None of the rats showed symptoms of kidney and liver toxicity during the term of the study. Administration of HPTP had decreased the acidity, increased gastric wall mucus and flattening of gastric mucosa and reducing erosive gastric damage area. HPTP also showed dose dependent increase in SOD, GPx activity and PGE(2) level and decrease MDA. H & E stain showed decreased infiltration of leucocytes with edema of submucosal layer. PAS staining showed intense uptake of magenta color of gastric wall mucus in rats fed with HPTP, and immunohistochemical staining of gastric mucosa revealed over-expression of HSP70 protein, down-expression of Bax protein and over expression of TGF-β in rats administered with HPTP. CONCLUSION: This study has revealed that chalcone1-(4-hydroxy-phenyl)-3-m-tolyl-propenone can serve as a safe and effective antiulcer agent as it has been proved to increase pH and gastric wall mucus, increase GPx, SOD, PGE(2), and decrease MDA level, ultimately, it has also contributes towards the over-expression of HSP protein andTGF-β, and down-expression of Bax protein. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-014-0303-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4339009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43390092015-02-25 Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats Dhiyaaldeen, Summaya M Amin, Zahra A Darvish, Pouya H Mustafa, Iman Fahmi Jamil, Mazen M Rouhollahi, Elham Abdulla, Mahmood A BMC Vet Res Research Article BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) can result in peptic ulcer disease (PUD) which is a common condition worldwide. The aim of this study was to evaluate the antiulcer properties of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone) (HPTP) chalcone in rats using indomethacin as ulcerogenic agent. RESULTS: None of the rats showed symptoms of kidney and liver toxicity during the term of the study. Administration of HPTP had decreased the acidity, increased gastric wall mucus and flattening of gastric mucosa and reducing erosive gastric damage area. HPTP also showed dose dependent increase in SOD, GPx activity and PGE(2) level and decrease MDA. H & E stain showed decreased infiltration of leucocytes with edema of submucosal layer. PAS staining showed intense uptake of magenta color of gastric wall mucus in rats fed with HPTP, and immunohistochemical staining of gastric mucosa revealed over-expression of HSP70 protein, down-expression of Bax protein and over expression of TGF-β in rats administered with HPTP. CONCLUSION: This study has revealed that chalcone1-(4-hydroxy-phenyl)-3-m-tolyl-propenone can serve as a safe and effective antiulcer agent as it has been proved to increase pH and gastric wall mucus, increase GPx, SOD, PGE(2), and decrease MDA level, ultimately, it has also contributes towards the over-expression of HSP protein andTGF-β, and down-expression of Bax protein. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-014-0303-7) contains supplementary material, which is available to authorized users. BioMed Central 2014-12-31 /pmc/articles/PMC4339009/ /pubmed/25551777 http://dx.doi.org/10.1186/s12917-014-0303-7 Text en © Dhiyaaldeen et al.; licensee BioMed Central. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Dhiyaaldeen, Summaya M Amin, Zahra A Darvish, Pouya H Mustafa, Iman Fahmi Jamil, Mazen M Rouhollahi, Elham Abdulla, Mahmood A Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats |
title | Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats |
title_full | Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats |
title_fullStr | Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats |
title_full_unstemmed | Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats |
title_short | Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats |
title_sort | protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339009/ https://www.ncbi.nlm.nih.gov/pubmed/25551777 http://dx.doi.org/10.1186/s12917-014-0303-7 |
work_keys_str_mv | AT dhiyaaldeensummayam protectiveeffectsof14hydroxyphenyl3mtolylpropenonechalconeinindomethacininducedgastricerosivedamageinrats AT aminzahraa protectiveeffectsof14hydroxyphenyl3mtolylpropenonechalconeinindomethacininducedgastricerosivedamageinrats AT darvishpouyah protectiveeffectsof14hydroxyphenyl3mtolylpropenonechalconeinindomethacininducedgastricerosivedamageinrats AT mustafaimanfahmi protectiveeffectsof14hydroxyphenyl3mtolylpropenonechalconeinindomethacininducedgastricerosivedamageinrats AT jamilmazenm protectiveeffectsof14hydroxyphenyl3mtolylpropenonechalconeinindomethacininducedgastricerosivedamageinrats AT rouhollahielham protectiveeffectsof14hydroxyphenyl3mtolylpropenonechalconeinindomethacininducedgastricerosivedamageinrats AT abdullamahmooda protectiveeffectsof14hydroxyphenyl3mtolylpropenonechalconeinindomethacininducedgastricerosivedamageinrats |