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Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells

BACKGROUND: Normal epithelial cells and carcinoma cells can acquire invasiveness by epithelial-to-mesenchymal transition (EMT), a process of considerable cellular remodeling. The endosomal/lysosomal compartment is a principal site of intracellular protein degradation. Lysosomal cathepsin proteases a...

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Detalles Bibliográficos
Autores principales:	Kern, Ursula, Wischnewski, Vladimir, Biniossek, Martin L, Schilling, Oliver, Reinheckel, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339013/ https://www.ncbi.nlm.nih.gov/pubmed/25744631 http://dx.doi.org/10.1186/s12943-015-0313-5

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