A THEMIS:SHP1 complex promotes T-cell survival

THEMIS is critical for conventional T-cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates with the phosphatases SHP1 and SHP2. This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr-phosphorylation-independen...

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Detalles Bibliográficos
Autores principales: Paster, Wolfgang, Bruger, Annika M, Katsch, Kristin, Grégoire, Claude, Roncagalli, Romain, Fu, Guo, Gascoigne, Nicholas RJ, Nika, Konstantina, Cohnen, Andre, Feller, Stephan M, Simister, Philip C, Molder, Kelly C, Cordoba, Shaun-Paul, Dushek, Omer, Malissen, Bernard, Acuto, Oreste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339124/
https://www.ncbi.nlm.nih.gov/pubmed/25535246
http://dx.doi.org/10.15252/embj.201387725

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