TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

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The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to promote t-loop unwinding is unclear. Here, we...

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Detalles Bibliográficos
Autores principales: Sarek, Grzegorz, Vannier, Jean-Baptiste, Panier, Stephanie, Petrini, John H.J., Boulton, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339303/
https://www.ncbi.nlm.nih.gov/pubmed/25620558
http://dx.doi.org/10.1016/j.molcel.2014.12.024

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