The influence of life events on first and recurrent admissions in bipolar disorder

BACKGROUND: Life events play an important role in the onset and course of bipolar disorder. We will test the influence of life events on first and recurrent admissions in bipolar disorder and their interaction to test the kindling hypothesis. METHODS: We collected information about life events and a...

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Autores principales: Kemner, Sanne M, van Haren, Neeltje EM, Bootsman, Florian, Eijkemans, Marinus JC, Vonk, Ronald, van der Schot, Astrid C, Nolen, Willem A, Hillegers, Manon HJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339321/
https://www.ncbi.nlm.nih.gov/pubmed/25717427
http://dx.doi.org/10.1186/s40345-015-0022-4
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author Kemner, Sanne M
van Haren, Neeltje EM
Bootsman, Florian
Eijkemans, Marinus JC
Vonk, Ronald
van der Schot, Astrid C
Nolen, Willem A
Hillegers, Manon HJ
author_facet Kemner, Sanne M
van Haren, Neeltje EM
Bootsman, Florian
Eijkemans, Marinus JC
Vonk, Ronald
van der Schot, Astrid C
Nolen, Willem A
Hillegers, Manon HJ
author_sort Kemner, Sanne M
collection PubMed
description BACKGROUND: Life events play an important role in the onset and course of bipolar disorder. We will test the influence of life events on first and recurrent admissions in bipolar disorder and their interaction to test the kindling hypothesis. METHODS: We collected information about life events and admissions across the life span in 51 bipolar patients. We constructed four models to explore the decay of life event effects on admissions. To test their interaction, we used the Andersen-Gill model. RESULTS: The relationship between life events and admissions was best described with a model in which the effects of life events gradually decayed by 25% per year. Both life event load and recurrent admissions significantly increased the risk of both first and subsequent admissions. No significant interaction between life event load and number of admissions was found. CONCLUSIONS: Life events increase the risk of both first and recurrent admissions in bipolar disorder. We found no significant interaction between life events and admissions, but the effect of life events on admissions decreases after the first admission which is in line with the kindling hypothesis.
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spelling pubmed-43393212015-02-26 The influence of life events on first and recurrent admissions in bipolar disorder Kemner, Sanne M van Haren, Neeltje EM Bootsman, Florian Eijkemans, Marinus JC Vonk, Ronald van der Schot, Astrid C Nolen, Willem A Hillegers, Manon HJ Int J Bipolar Disord Research BACKGROUND: Life events play an important role in the onset and course of bipolar disorder. We will test the influence of life events on first and recurrent admissions in bipolar disorder and their interaction to test the kindling hypothesis. METHODS: We collected information about life events and admissions across the life span in 51 bipolar patients. We constructed four models to explore the decay of life event effects on admissions. To test their interaction, we used the Andersen-Gill model. RESULTS: The relationship between life events and admissions was best described with a model in which the effects of life events gradually decayed by 25% per year. Both life event load and recurrent admissions significantly increased the risk of both first and subsequent admissions. No significant interaction between life event load and number of admissions was found. CONCLUSIONS: Life events increase the risk of both first and recurrent admissions in bipolar disorder. We found no significant interaction between life events and admissions, but the effect of life events on admissions decreases after the first admission which is in line with the kindling hypothesis. Springer Berlin Heidelberg 2015-02-25 /pmc/articles/PMC4339321/ /pubmed/25717427 http://dx.doi.org/10.1186/s40345-015-0022-4 Text en © Kemner et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Kemner, Sanne M
van Haren, Neeltje EM
Bootsman, Florian
Eijkemans, Marinus JC
Vonk, Ronald
van der Schot, Astrid C
Nolen, Willem A
Hillegers, Manon HJ
The influence of life events on first and recurrent admissions in bipolar disorder
title The influence of life events on first and recurrent admissions in bipolar disorder
title_full The influence of life events on first and recurrent admissions in bipolar disorder
title_fullStr The influence of life events on first and recurrent admissions in bipolar disorder
title_full_unstemmed The influence of life events on first and recurrent admissions in bipolar disorder
title_short The influence of life events on first and recurrent admissions in bipolar disorder
title_sort influence of life events on first and recurrent admissions in bipolar disorder
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339321/
https://www.ncbi.nlm.nih.gov/pubmed/25717427
http://dx.doi.org/10.1186/s40345-015-0022-4
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