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Per-Oral Immunization with Antigen-Conjugated Nanoparticles followed by Sub-Cutaneous Boosting Immunization Induces Long-Lasting Mucosal and Systemic Antibody Responses in Mice
Food or water-borne enteric pathogens invade their hosts via intestinal mucosal surfaces, thus developing effective oral vaccines would greatly reduce the burden of infectious diseases. The nature of the antigen, as well as the mode of its internalization in the intestinal mucosa affects the ensuing...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339372/ https://www.ncbi.nlm.nih.gov/pubmed/25710518 http://dx.doi.org/10.1371/journal.pone.0118067 |