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Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

BACKGROUND: The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic heterogeneity resulting from clonal evolution a...

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Detalles Bibliográficos
Autores principales:	Schwarz, Roland F., Ng, Charlotte K. Y., Cooke, Susanna L., Newman, Scott, Temple, Jillian, Piskorz, Anna M., Gale, Davina, Sayal, Karen, Murtaza, Muhammed, Baldwin, Peter J., Rosenfeld, Nitzan, Earl, Helena M., Sala, Evis, Jimenez-Linan, Mercedes, Parkinson, Christine A., Markowetz, Florian, Brenton, James D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339382/ https://www.ncbi.nlm.nih.gov/pubmed/25710373 http://dx.doi.org/10.1371/journal.pmed.1001789

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