Hyperglycemia diverts dividing stem cells to pathological adipogenesis

This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue. The mechanism involves the diversion of stem cells to pathological adipocytes when they divide in hyperglycemia.

Detalles Bibliográficos
Autores principales: Hascall, Vincent, Wang, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339424/
https://www.ncbi.nlm.nih.gov/pubmed/25689074
http://dx.doi.org/10.1186/scrt518
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author Hascall, Vincent
Wang, Aimin
author_facet Hascall, Vincent
Wang, Aimin
author_sort Hascall, Vincent
collection PubMed
description This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue. The mechanism involves the diversion of stem cells to pathological adipocytes when they divide in hyperglycemia.
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spelling pubmed-43394242015-02-26 Hyperglycemia diverts dividing stem cells to pathological adipogenesis Hascall, Vincent Wang, Aimin Stem Cell Res Ther Commentary This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue. The mechanism involves the diversion of stem cells to pathological adipocytes when they divide in hyperglycemia. BioMed Central 2014-11-17 /pmc/articles/PMC4339424/ /pubmed/25689074 http://dx.doi.org/10.1186/scrt518 Text en © Hascall and Wang; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Hascall, Vincent
Wang, Aimin
Hyperglycemia diverts dividing stem cells to pathological adipogenesis
title Hyperglycemia diverts dividing stem cells to pathological adipogenesis
title_full Hyperglycemia diverts dividing stem cells to pathological adipogenesis
title_fullStr Hyperglycemia diverts dividing stem cells to pathological adipogenesis
title_full_unstemmed Hyperglycemia diverts dividing stem cells to pathological adipogenesis
title_short Hyperglycemia diverts dividing stem cells to pathological adipogenesis
title_sort hyperglycemia diverts dividing stem cells to pathological adipogenesis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339424/
https://www.ncbi.nlm.nih.gov/pubmed/25689074
http://dx.doi.org/10.1186/scrt518
work_keys_str_mv AT hascallvincent hyperglycemiadivertsdividingstemcellstopathologicaladipogenesis
AT wangaimin hyperglycemiadivertsdividingstemcellstopathologicaladipogenesis

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