Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid

Objective: To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates. Methods: The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1(st), 2010 and May 1(st), 2012 were analyzed retrospectively. The t...

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Autores principales: Yan, Ya-Min, Fan, Qiao-Ling, Li, Ai-Qiu, Chen, Jia-Ling, Dong, Fei-Fei, Gong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339556/
https://www.ncbi.nlm.nih.gov/pubmed/25755854
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author Yan, Ya-Min
Fan, Qiao-Ling
Li, Ai-Qiu
Chen, Jia-Ling
Dong, Fei-Fei
Gong, Mei
author_facet Yan, Ya-Min
Fan, Qiao-Ling
Li, Ai-Qiu
Chen, Jia-Ling
Dong, Fei-Fei
Gong, Mei
author_sort Yan, Ya-Min
collection PubMed
description Objective: To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates. Methods: The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1(st), 2010 and May 1(st), 2012 were analyzed retrospectively. The treatment procedure for drug extravasation adhered to the protocol in neonatal department. The information including age, sex, weight, diagnosis, size of affected area, site of extravasation and treatment was collected. Findings : The extravasation injuries alleviated and the symptoms improved after treatment, no adverse drug effects were reported with use of hyaluronidase and hirudoid. Conclusion: The treatment appeared to be beneficial in the management of extravasations of various medications in neonates and may be useful in reducing the severity of cutaneous toxicosis. However, further studies with large samples are still needed to assess the effectiveness and safety of hyaluronidase and hirudoid.
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spelling pubmed-43395562015-03-09 Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid Yan, Ya-Min Fan, Qiao-Ling Li, Ai-Qiu Chen, Jia-Ling Dong, Fei-Fei Gong, Mei Iran J Pediatr Original Article Objective: To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates. Methods: The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1(st), 2010 and May 1(st), 2012 were analyzed retrospectively. The treatment procedure for drug extravasation adhered to the protocol in neonatal department. The information including age, sex, weight, diagnosis, size of affected area, site of extravasation and treatment was collected. Findings : The extravasation injuries alleviated and the symptoms improved after treatment, no adverse drug effects were reported with use of hyaluronidase and hirudoid. Conclusion: The treatment appeared to be beneficial in the management of extravasations of various medications in neonates and may be useful in reducing the severity of cutaneous toxicosis. However, further studies with large samples are still needed to assess the effectiveness and safety of hyaluronidase and hirudoid. Tehran University of Medical Sciences 2014-08 2014-07-03 /pmc/articles/PMC4339556/ /pubmed/25755854 Text en Copyright © 2014 by Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, All rights reserved This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yan, Ya-Min
Fan, Qiao-Ling
Li, Ai-Qiu
Chen, Jia-Ling
Dong, Fei-Fei
Gong, Mei
Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid
title Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid
title_full Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid
title_fullStr Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid
title_full_unstemmed Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid
title_short Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid
title_sort treatment of cutaneous injuries of neonates induced by drug extravasation with hyaluronidase and hirudoid
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339556/
https://www.ncbi.nlm.nih.gov/pubmed/25755854
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