2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of...

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Detalles Bibliográficos
Autores principales: Sayer, James R., Walldén, Karin, Pesnot, Thomas, Campbell, Frederick, Gane, Paul J., Simone, Michela, Koss, Hans, Buelens, Floris, Boyle, Timothy P., Selwood, David L., Waksman, Gabriel, Tabor, Alethea B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339681/
https://www.ncbi.nlm.nih.gov/pubmed/25438770
http://dx.doi.org/10.1016/j.bmc.2014.09.036

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