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Data-driven identification of structural alerts for mitigating the risk of drug-induced human liver injuries
BACKGROUND: The use of structural alerts to de-prioritize compounds with undesirable features as drug candidates has been gaining in popularity. Hundreds of molecular structural moieties have been proposed as structural alerts. An emerging issue is that strict application of these alerts will result...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339691/ https://www.ncbi.nlm.nih.gov/pubmed/25717346 http://dx.doi.org/10.1186/s13321-015-0053-y |