Cargando…

The Phosphoinositide 3-Kinase Signaling Pathway is Involved in the Control of Modified Low-Density Lipoprotein Uptake by Human Macrophages

The transformation of macrophages into lipid-loaded foam cells is a critical early event in the pathogenesis of atherosclerosis. Both receptor-mediated uptake of modified LDL, mediated primarily by scavenger receptors-A (SR-A) and CD36 along with other proteins such as lipoprotein lipase (LPL), and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Michael, Daryn R., Davies, Thomas S., Laubertová, Lucia, Gallagher, Hayley, Ramji, Dipak P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339697/ https://www.ncbi.nlm.nih.gov/pubmed/25663263 http://dx.doi.org/10.1007/s11745-015-3993-0

Ejemplares similares

TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: A dominant role for Smad-2
por: Michael, Daryn R., et al.
Publicado: (2012)

The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways
por: Buckley, Melanie L., et al.
Publicado: (2019)

The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake
por: Salter, Rebecca C., et al.
Publicado: (2016)

The interferon-γ-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3
por: Harris, Sandra M., et al.
Publicado: (2008)

Differential regulation of macropinocytosis in macrophages by cytokines: Implications for foam cell formation and atherosclerosis()
por: Michael, Daryn R., et al.
Publicado: (2013)

A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression
por: Huwait, Etimad A., et al.
Publicado: (2011)

Whole-Cell Analysis of Low-Density Lipoprotein Uptake by Macrophages Using STEM Tomography
por: Baudoin, Jean-Pierre, et al.
Publicado: (2013)

The anti-atherogenic cytokine interleukin-33 inhibits the expression of a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 in human macrophages: Requirement of extracellular signal-regulated kinase, c-Jun N-terminal kinase and phosphoinositide 3-kinase signaling pathways()
por: Ashlin, Tim G., et al.
Publicado: (2014)

Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells
Publicado: (1985)

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages
por: Laguna-Fernandez, Andres, et al.
Publicado: (2018)

Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages
por: Demina, Ekaterina P., et al.
Publicado: (2021)

Palmitate and minimally-modified low-density lipoprotein cooperatively promote inflammatory responses in macrophages
por: Ann, Soo-jin, et al.
Publicado: (2018)

Metformin protects against oxidized low density lipoprotein-induced macrophage apoptosis and inhibits lipid uptake
por: Huangfu, Ning, et al.
Publicado: (2018)

Effect of cell density on binding and uptake of low density lipoprotein by human fibroblasts
Publicado: (1979)

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
Publicado: (1996)

Oxidized high-density lipoprotein promotes CD36 palmitoylation and increases lipid uptake in macrophages
por: Zhang, Yun, et al.
Publicado: (2022)

Metformin improved oxidized low-density lipoprotein-impaired mitochondrial function and increased glucose uptake involving Akt-AS160 pathway in raw264.7 macrophages
por: He, Xuan, et al.
Publicado: (2019)

Neat1 regulates oxidized low-density lipoprotein-induced inflammation and lipid uptake in macrophages via paraspeckle formation
por: Huang-Fu, Ning, et al.
Publicado: (2018)

The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-Jun
por: Salter, Rebecca C., et al.
Publicado: (2011)

Evidence for low-density lipoprotein receptor-mediated uptake of benzoporphyrin derivative.
por: Allison, B. A., et al.
Publicado: (1994)

Trichomonas vaginalis is dependent on uptake and degradation of human low density lipoproteins
Publicado: (1984)

Human macrophages limit oxidation products in low density lipoprotein
por: Hultén, Lillemor Mattsson, et al.
Publicado: (2005)

Punicalagin Induces Serum Low-Density Lipoprotein Influx to Macrophages
por: Atrahimovich, Dana, et al.
Publicado: (2016)

Receptor activities for low-density lipoprotein and acetylated low- density lipoprotein in a mouse macrophage cell line (IC21) and in human monocyte-derived macrophages
Publicado: (1981)

A critical role for the Sp1-binding sites in the transforming growth factor-β-mediated inhibition of lipoprotein lipase gene expression in macrophages
por: Irvine, Scott A., et al.
Publicado: (2005)

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)
por: Huang, Xueqin, et al.
Publicado: (2023)

Macrophage uptake of oxidized and acetylated low-density lipoproteins and generation of reactive oxygen species are regulated by linear stiffness of the growth surface
por: Gruber, Erika J., et al.
Publicado: (2021)

High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPARγ/CD36 Pathway in Inflammatory Adipocytes
por: Zhong, Qiaoqing, et al.
Publicado: (2015)

Lipid composition of circulating multiple-modified low density lipoprotein
por: Zakiev, E. R., et al.
Publicado: (2016)

Carbohydrate composition of circulating multiple-modified low-density lipoprotein
por: Zakiev, Emile R, et al.
Publicado: (2016)

Cholesterol-Dependent Anaplasma phagocytophilum Exploits the Low-Density Lipoprotein Uptake Pathway
por: Xiong, Qingming, et al.
Publicado: (2009)

Low-Density Lipoprotein Receptor Contributes to β-Carotene Uptake in the Maternal Liver
por: Shete, Varsha, et al.
Publicado: (2016)

A Unique Combination of Nutritionally Active Ingredients Can Prevent Several Key Processes Associated with Atherosclerosis In Vitro
por: Moss, Joe W. E., et al.
Publicado: (2016)

Different responses to oxidized low-density lipoproteins in human polarized macrophages
por: Hirose, Kuniaki, et al.
Publicado: (2011)

Native low density lipoprotein promotes lipid raft formation in macrophages
por: SONG, JIAN, et al.
Publicado: (2016)

Oxidized Low‐Density Lipoprotein Induces Macrophage Production of Prothrombotic Microparticles
por: Marchini, Julio F., et al.
Publicado: (2020)

Involvement of Low‐Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension
por: Umar, Soban, et al.
Publicado: (2020)

Nlrp3, Csf3, and Edn1 in Macrophage Response to Saturated Fatty Acids and Modified Low-Density Lipoprotein
por: Youk, Harin, et al.
Publicado: (2020)

CD9 Tetraspanin Interacts with CD36 on the Surface of Macrophages: A Possible Regulatory Influence on Uptake of Oxidized Low Density Lipoprotein
por: Huang, Wenxin, et al.
Publicado: (2011)

BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages
por: Koga, Mitsuhisa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_s83chdi13g2iq7hdkv2vq9pvjc