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Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials

OBJECTIVE: To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in Africa, the Americas, South-East Asia and the Western Pacific. METHODS: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from...

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Autores principales: Hayes, Daniel J, van Buuren, Stef, ter Kuile, Feiko O, Stasinopoulos, D Mikis, Rigby, Robert A, Terlouw, Dianne J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Health Organization 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339962/
https://www.ncbi.nlm.nih.gov/pubmed/25883400
http://dx.doi.org/10.2471/BLT.14.139113
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author Hayes, Daniel J
van Buuren, Stef
ter Kuile, Feiko O
Stasinopoulos, D Mikis
Rigby, Robert A
Terlouw, Dianne J
author_facet Hayes, Daniel J
van Buuren, Stef
ter Kuile, Feiko O
Stasinopoulos, D Mikis
Rigby, Robert A
Terlouw, Dianne J
author_sort Hayes, Daniel J
collection PubMed
description OBJECTIVE: To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in Africa, the Americas, South-East Asia and the Western Pacific. METHODS: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) older than 14 days and younger than 50 years in 64 malaria-endemic countries. Regional growth references were generated using a generalized additive model for location, scale and shape by combining data with varying distributions from a range of sources. Countries were weighted by their population at risk of malaria to enable references to be used in optimizing the dosing of antimalarials. FINDINGS: Large differences in weight-for-age distributions existed between the regions and between the regions and global growth standards. For example, the average adult male from the Americas weighed 68.1 kg – 6.0 kg more than males in South-East Asia and the Western Pacific (average: 62.1 kg). For adult women, the difference was over 10.4 kg: the average was 60.4 kg in the Americas and 50.0 kg in South-East Asia and the Western Pacific. CONCLUSION: There were substantial variations in weight-for-age growth curves between malaria-endemic areas. The growth reference charts derived here can be used to guide the evidence-based optimization of aged-based dosing regimens for antimalarials and other drugs often prescribed by age.
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spelling pubmed-43399622015-04-16 Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials Hayes, Daniel J van Buuren, Stef ter Kuile, Feiko O Stasinopoulos, D Mikis Rigby, Robert A Terlouw, Dianne J Bull World Health Organ Research OBJECTIVE: To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in Africa, the Americas, South-East Asia and the Western Pacific. METHODS: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) older than 14 days and younger than 50 years in 64 malaria-endemic countries. Regional growth references were generated using a generalized additive model for location, scale and shape by combining data with varying distributions from a range of sources. Countries were weighted by their population at risk of malaria to enable references to be used in optimizing the dosing of antimalarials. FINDINGS: Large differences in weight-for-age distributions existed between the regions and between the regions and global growth standards. For example, the average adult male from the Americas weighed 68.1 kg – 6.0 kg more than males in South-East Asia and the Western Pacific (average: 62.1 kg). For adult women, the difference was over 10.4 kg: the average was 60.4 kg in the Americas and 50.0 kg in South-East Asia and the Western Pacific. CONCLUSION: There were substantial variations in weight-for-age growth curves between malaria-endemic areas. The growth reference charts derived here can be used to guide the evidence-based optimization of aged-based dosing regimens for antimalarials and other drugs often prescribed by age. World Health Organization 2015-02-01 2014-11-20 /pmc/articles/PMC4339962/ /pubmed/25883400 http://dx.doi.org/10.2471/BLT.14.139113 Text en (c) 2015 The authors; licensee World Health Organization. This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (http://creativecommons.org/licenses/by/3.0/igo/legalcode), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any suggestion that WHO or this article endorse any specific organization or products. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL.
spellingShingle Research
Hayes, Daniel J
van Buuren, Stef
ter Kuile, Feiko O
Stasinopoulos, D Mikis
Rigby, Robert A
Terlouw, Dianne J
Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials
title Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials
title_full Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials
title_fullStr Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials
title_full_unstemmed Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials
title_short Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials
title_sort developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339962/
https://www.ncbi.nlm.nih.gov/pubmed/25883400
http://dx.doi.org/10.2471/BLT.14.139113
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