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Neurogenesis in the adult peripheral nervous system☆

Most researchers believe that neurogenesis in mature mammals is restricted only to the subgranular zone of the dentate gyrus and the subventricular zone of the lateral ventricle in the central nervous system. In the peripheral nervous system, neurogenesis is thought to be active only during prenatal...

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Autores principales: Czaja, Krzysztof, Fornaro, Michele, Geuna, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340017/
https://www.ncbi.nlm.nih.gov/pubmed/25722694
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.14.002
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author Czaja, Krzysztof
Fornaro, Michele
Geuna, Stefano
author_facet Czaja, Krzysztof
Fornaro, Michele
Geuna, Stefano
author_sort Czaja, Krzysztof
collection PubMed
description Most researchers believe that neurogenesis in mature mammals is restricted only to the subgranular zone of the dentate gyrus and the subventricular zone of the lateral ventricle in the central nervous system. In the peripheral nervous system, neurogenesis is thought to be active only during prenatal development, with the exception of the olfactory neuroepithelium. However, sensory ganglia in the adult peripheral nervous system have been reported to contain precursor cells that can proliferate in vitro and be induced to differentiate into neurons. The occurrence of insult-induced neurogenesis, which has been reported by several investigators in the brain, is limited to a few recent reports for the peripheral nervous system. These reports suggest that damage to the adult nervous system induces mechanisms similar to those that control the generation of new neurons during prenatal development. Understanding conditions under which neurogenesis can be induced in physiologically non-neurogenic regions in adults is one of the major challenges for developing therapeutic strategies to repair neurological damage. However, the induced neurogenesis in the peripheral nervous system is still largely unexplored. This review presents the history of research on adult neurogenesis in the peripheral nervous system, which dates back more than 100 years and reveals the evidence on the under estimated potential for generation of new neurons in the adult peripheral nervous system.
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spelling pubmed-43400172015-02-26 Neurogenesis in the adult peripheral nervous system☆ Czaja, Krzysztof Fornaro, Michele Geuna, Stefano Neural Regen Res Special Issue Most researchers believe that neurogenesis in mature mammals is restricted only to the subgranular zone of the dentate gyrus and the subventricular zone of the lateral ventricle in the central nervous system. In the peripheral nervous system, neurogenesis is thought to be active only during prenatal development, with the exception of the olfactory neuroepithelium. However, sensory ganglia in the adult peripheral nervous system have been reported to contain precursor cells that can proliferate in vitro and be induced to differentiate into neurons. The occurrence of insult-induced neurogenesis, which has been reported by several investigators in the brain, is limited to a few recent reports for the peripheral nervous system. These reports suggest that damage to the adult nervous system induces mechanisms similar to those that control the generation of new neurons during prenatal development. Understanding conditions under which neurogenesis can be induced in physiologically non-neurogenic regions in adults is one of the major challenges for developing therapeutic strategies to repair neurological damage. However, the induced neurogenesis in the peripheral nervous system is still largely unexplored. This review presents the history of research on adult neurogenesis in the peripheral nervous system, which dates back more than 100 years and reveals the evidence on the under estimated potential for generation of new neurons in the adult peripheral nervous system. Medknow Publications & Media Pvt Ltd 2012-05-15 /pmc/articles/PMC4340017/ /pubmed/25722694 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.14.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue
Czaja, Krzysztof
Fornaro, Michele
Geuna, Stefano
Neurogenesis in the adult peripheral nervous system☆
title Neurogenesis in the adult peripheral nervous system☆
title_full Neurogenesis in the adult peripheral nervous system☆
title_fullStr Neurogenesis in the adult peripheral nervous system☆
title_full_unstemmed Neurogenesis in the adult peripheral nervous system☆
title_short Neurogenesis in the adult peripheral nervous system☆
title_sort neurogenesis in the adult peripheral nervous system☆
topic Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340017/
https://www.ncbi.nlm.nih.gov/pubmed/25722694
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.14.002
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