Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆

Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat...

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Autores principales: Zhao, Chen, Qi, Li, Wu, Luyi, Yi, Tao, Wu, Huangan, Guo, Xinxin, Zhou, Cili, Liu, Huirong, Wang, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Acupuncture and Moxibustion and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340031/
https://www.ncbi.nlm.nih.gov/pubmed/25722707
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.004
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author Zhao, Chen
Qi, Li
Wu, Luyi
Yi, Tao
Wu, Huangan
Guo, Xinxin
Zhou, Cili
Liu, Huirong
Wang, Xiaomei
author_facet Zhao, Chen
Qi, Li
Wu, Luyi
Yi, Tao
Wu, Huangan
Guo, Xinxin
Zhou, Cili
Liu, Huirong
Wang, Xiaomei
author_sort Zhao, Chen
collection PubMed
description Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia.
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spelling pubmed-43400312015-02-26 Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆ Zhao, Chen Qi, Li Wu, Luyi Yi, Tao Wu, Huangan Guo, Xinxin Zhou, Cili Liu, Huirong Wang, Xiaomei Neural Regen Res Research and Report: Acupuncture and Moxibustion and Neural Regeneration Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia. Medknow Publications & Media Pvt Ltd 2012-05-25 /pmc/articles/PMC4340031/ /pubmed/25722707 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Acupuncture and Moxibustion and Neural Regeneration
Zhao, Chen
Qi, Li
Wu, Luyi
Yi, Tao
Wu, Huangan
Guo, Xinxin
Zhou, Cili
Liu, Huirong
Wang, Xiaomei
Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆
title Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆
title_full Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆
title_fullStr Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆
title_full_unstemmed Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆
title_short Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆
title_sort suspended moxibustion at tianshu (st25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity☆
topic Research and Report: Acupuncture and Moxibustion and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340031/
https://www.ncbi.nlm.nih.gov/pubmed/25722707
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.004
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