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Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation

In this study, Schwann cells, at a density of 1 × 10(5) cells/well, were cultured on regenerated silk fibroin nanofibers (305 ± 84 nm) prepared using the electrospinning method. Schwann cells cultured on the silk fibroin nanofibers appeared more ordered, their processes extended further, and they fo...

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Detalles Bibliográficos
Autores principales: Hu, Aijun, Zuo, Baoqi, Zhang, Feng, Lan, Qing, Zhang, Huanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340035/
https://www.ncbi.nlm.nih.gov/pubmed/25722711
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.008
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author Hu, Aijun
Zuo, Baoqi
Zhang, Feng
Lan, Qing
Zhang, Huanxiang
author_facet Hu, Aijun
Zuo, Baoqi
Zhang, Feng
Lan, Qing
Zhang, Huanxiang
author_sort Hu, Aijun
collection PubMed
description In this study, Schwann cells, at a density of 1 × 10(5) cells/well, were cultured on regenerated silk fibroin nanofibers (305 ± 84 nm) prepared using the electrospinning method. Schwann cells cultured on the silk fibroin nanofibers appeared more ordered, their processes extended further, and they formed more extensive and complex interconnections. In addition, the silk fibroin nanofibers had no impact on the proliferation of Schwann cells or on the secretion of ciliary neurotrophic factor, brain-derived neurotrophic factor or nerve growth factor. These findings indicate that regenerated electrospun silk fibroin nanofibers can promote Schwann cell adhesion, growth and proliferation, and have excellent biocompatibility.
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spelling pubmed-43400352015-02-26 Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation Hu, Aijun Zuo, Baoqi Zhang, Feng Lan, Qing Zhang, Huanxiang Neural Regen Res Techniques and Methods: Emerging Technology in Neural Regeneration In this study, Schwann cells, at a density of 1 × 10(5) cells/well, were cultured on regenerated silk fibroin nanofibers (305 ± 84 nm) prepared using the electrospinning method. Schwann cells cultured on the silk fibroin nanofibers appeared more ordered, their processes extended further, and they formed more extensive and complex interconnections. In addition, the silk fibroin nanofibers had no impact on the proliferation of Schwann cells or on the secretion of ciliary neurotrophic factor, brain-derived neurotrophic factor or nerve growth factor. These findings indicate that regenerated electrospun silk fibroin nanofibers can promote Schwann cell adhesion, growth and proliferation, and have excellent biocompatibility. Medknow Publications & Media Pvt Ltd 2012-05-25 /pmc/articles/PMC4340035/ /pubmed/25722711 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.008 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Techniques and Methods: Emerging Technology in Neural Regeneration
Hu, Aijun
Zuo, Baoqi
Zhang, Feng
Lan, Qing
Zhang, Huanxiang
Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation
title Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation
title_full Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation
title_fullStr Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation
title_full_unstemmed Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation
title_short Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation
title_sort electrospun silk fibroin nanofibers promote schwann cell adhesion, growth and proliferation
topic Techniques and Methods: Emerging Technology in Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340035/
https://www.ncbi.nlm.nih.gov/pubmed/25722711
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.008
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