Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆

Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by (60)Co irradiation for 24 hours prior to implantation in the right thigh of rats...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qing, Yang, Xiaolei, Ren, Ming, Hu, Yulin, Chen, Qiang, Xing, Lei, Meng, Chunyang, Liu, Tiemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Techniques and Methods: Emerging Technology in Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340036/
https://www.ncbi.nlm.nih.gov/pubmed/25722712
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.009
Descripción
Sumario:Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by (60)Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation.

Ejemplares similares