Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆

Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by (60)Co irradiation for 24 hours prior to implantation in the right thigh of rats...

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Detalles Bibliográficos
Autores principales: Wang, Qing, Yang, Xiaolei, Ren, Ming, Hu, Yulin, Chen, Qiang, Xing, Lei, Meng, Chunyang, Liu, Tiemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Techniques and Methods: Emerging Technology in Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340036/
https://www.ncbi.nlm.nih.gov/pubmed/25722712
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.009
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author Wang, Qing
Yang, Xiaolei
Ren, Ming
Hu, Yulin
Chen, Qiang
Xing, Lei
Meng, Chunyang
Liu, Tiemei
author_facet Wang, Qing
Yang, Xiaolei
Ren, Ming
Hu, Yulin
Chen, Qiang
Xing, Lei
Meng, Chunyang
Liu, Tiemei
author_sort Wang, Qing
collection PubMed
description Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by (60)Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation.
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spelling pubmed-43400362015-02-26 Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆ Wang, Qing Yang, Xiaolei Ren, Ming Hu, Yulin Chen, Qiang Xing, Lei Meng, Chunyang Liu, Tiemei Neural Regen Res Techniques and Methods: Emerging Technology in Neural Regeneration Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by (60)Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation. Medknow Publications & Media Pvt Ltd 2012-05-25 /pmc/articles/PMC4340036/ /pubmed/25722712 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.009 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Techniques and Methods: Emerging Technology in Neural Regeneration
Wang, Qing
Yang, Xiaolei
Ren, Ming
Hu, Yulin
Chen, Qiang
Xing, Lei
Meng, Chunyang
Liu, Tiemei
Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆
title Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆
title_full Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆
title_fullStr Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆
title_full_unstemmed Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆
title_short Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair☆
title_sort effect of chitosan/type i collagen/gelatin composites in biocompatibility and nerve repair☆
topic Techniques and Methods: Emerging Technology in Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340036/
https://www.ncbi.nlm.nih.gov/pubmed/25722712
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.15.009
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