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Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)

Background: Previous reports, mostly from retrospective studies, suggested possible protective effects of both tea and coffee against endometrial cancer, but recent reports from prospective studies generally showed weaker or null associations. Objectives: We investigated endometrial cancer risk in r...

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Autores principales: Yang, TienYu Owen, Crowe, Francesca, Cairns, Benjamin J, Reeves, Gillian K, Beral, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Nutrition 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340062/
https://www.ncbi.nlm.nih.gov/pubmed/25733642
http://dx.doi.org/10.3945/ajcn.113.081836
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author Yang, TienYu Owen
Crowe, Francesca
Cairns, Benjamin J
Reeves, Gillian K
Beral, Valerie
author_facet Yang, TienYu Owen
Crowe, Francesca
Cairns, Benjamin J
Reeves, Gillian K
Beral, Valerie
author_sort Yang, TienYu Owen
collection PubMed
description Background: Previous reports, mostly from retrospective studies, suggested possible protective effects of both tea and coffee against endometrial cancer, but recent reports from prospective studies generally showed weaker or null associations. Objectives: We investigated endometrial cancer risk in relation to tea and coffee consumption in a large prospective study and did a meta-analysis of published results. Design: Daily consumption of tea and coffee was recorded in 560,356 participants (without a hysterectomy) in the UK Million Women Study of whom 4067 women developed endometrial cancer during 5.2 million person-years of follow up (average: 9.3 y per woman). Results: With the use of Cox proportional hazards regression, we showed no significant association between endometrial cancer risk and consumption of either tea (multivariate adjusted RR per cup daily: 1.00; 95% CI: 0.98, 1.02) or coffee (RR per cup daily: 0.98; 95% CI: 0.96, 1.01). Our meta-analyses showed no significant association between endometrial cancer risk and tea consumption and a weak association for coffee consumption in prospective studies, but there may have been selective publication of only part of the evidence. Conclusions: There is little or no association between tea consumption and endometrial cancer risk. If there is any association with coffee consumption, it appears to be weak.
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spelling pubmed-43400622015-03-11 Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4) Yang, TienYu Owen Crowe, Francesca Cairns, Benjamin J Reeves, Gillian K Beral, Valerie Am J Clin Nutr Cancer Background: Previous reports, mostly from retrospective studies, suggested possible protective effects of both tea and coffee against endometrial cancer, but recent reports from prospective studies generally showed weaker or null associations. Objectives: We investigated endometrial cancer risk in relation to tea and coffee consumption in a large prospective study and did a meta-analysis of published results. Design: Daily consumption of tea and coffee was recorded in 560,356 participants (without a hysterectomy) in the UK Million Women Study of whom 4067 women developed endometrial cancer during 5.2 million person-years of follow up (average: 9.3 y per woman). Results: With the use of Cox proportional hazards regression, we showed no significant association between endometrial cancer risk and consumption of either tea (multivariate adjusted RR per cup daily: 1.00; 95% CI: 0.98, 1.02) or coffee (RR per cup daily: 0.98; 95% CI: 0.96, 1.01). Our meta-analyses showed no significant association between endometrial cancer risk and tea consumption and a weak association for coffee consumption in prospective studies, but there may have been selective publication of only part of the evidence. Conclusions: There is little or no association between tea consumption and endometrial cancer risk. If there is any association with coffee consumption, it appears to be weak. American Society for Nutrition 2015-03 2015-01-21 /pmc/articles/PMC4340062/ /pubmed/25733642 http://dx.doi.org/10.3945/ajcn.113.081836 Text en http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Cancer
Yang, TienYu Owen
Crowe, Francesca
Cairns, Benjamin J
Reeves, Gillian K
Beral, Valerie
Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)
title Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)
title_full Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)
title_fullStr Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)
title_full_unstemmed Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)
title_short Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)
title_sort tea and coffee and risk of endometrial cancer: cohort study and meta-analysis(1)(2)(3)(4)
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340062/
https://www.ncbi.nlm.nih.gov/pubmed/25733642
http://dx.doi.org/10.3945/ajcn.113.081836
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