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Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells

BACKGROUND: EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. The degradation of ERAD substrates involves mannose trimming of N-linked glycans; however the precise mechanism...

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Detalles Bibliográficos
Autores principales:	Sokołowska, Iwona, Piłka, Ewa S, Sandvig, Kirsten, Węgrzyn, Grzegorz, Słomińska-Wojewódzka, Monika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340280/ https://www.ncbi.nlm.nih.gov/pubmed/25655076 http://dx.doi.org/10.1186/s12860-015-0047-7

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