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ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

ApoA5 has a critical role in the regulation of plasma TG concentrations. In order to determine whether ApoA5 also impacts ectopic lipid deposition in liver and skeletal muscle, as well as tissue insulin sensitivity, we treated mice with an antisense oligonucleotide (ASO) to decrease hepatic expressi...

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Detalles Bibliográficos
Autores principales:	Camporez, João Paulo G., Kanda, Shoichi, Petersen, Max C., Jornayvaz, François R., Samuel, Varman T., Bhanot, Sanjay, Petersen, Kitt Falk, Jurczak, Michael J., Shulman, Gerald I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340301/ https://www.ncbi.nlm.nih.gov/pubmed/25548259 http://dx.doi.org/10.1194/jlr.M054080

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